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Fusion gene ID: 826 |
FusionGeneSummary for ADCY2_SAMM50 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY2_SAMM50 | Fusion gene ID: 826 | Hgene | Tgene | Gene symbol | ADCY2 | SAMM50 | Gene ID | 108 | 25813 |
| Gene name | adenylate cyclase 2 | SAMM50 sorting and assembly machinery component | |
| Synonyms | AC2|HBAC2 | CGI-51|OMP85|SAM50|TOB55|TRG-3|YNL026W | |
| Cytomap | 5p15.31 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | sorting and assembly machinery component 50 homologsorting and assembly machinery 50kDatransformation-related gene 3 protein | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q08462 | Q9Y512 | |
| Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000350028, ENST00000493161, ENST00000396202, | |
| Fusion gene scores | * DoF score | 20 X 19 X 5=1900 | 5 X 5 X 4=100 |
| # samples | 21 | 5 | |
| ** MAII score | log2(21/1900*10)=-3.17753818555219 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADCY2 [Title/Abstract] AND SAMM50 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SAMM50 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FS-A4F4-06A | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000338316 | ENST00000350028 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| 5CDS-intron | ENST00000338316 | ENST00000493161 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| 5CDS-5UTR | ENST00000338316 | ENST00000396202 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-3CDS | ENST00000537121 | ENST00000350028 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-intron | ENST00000537121 | ENST00000493161 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-5UTR | ENST00000537121 | ENST00000396202 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-3CDS | ENST00000513693 | ENST00000350028 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-intron | ENST00000513693 | ENST00000493161 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
| intron-5UTR | ENST00000513693 | ENST00000396202 | ADCY2 | chr5 | 7414883 | + | SAMM50 | chr22 | 44359166 | + |
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FusionProtFeatures for ADCY2_SAMM50 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY2 | SAMM50 |