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Fusion gene ID: 8250 |
FusionGeneSummary for CPM_DNM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPM_DNM3 | Fusion gene ID: 8250 | Hgene | Tgene | Gene symbol | CPM | DNM3 | Gene ID | 1368 | 26052 |
| Gene name | carboxypeptidase M | dynamin 3 | |
| Synonyms | - | Dyna III | |
| Cytomap | 12q15 | 1q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | dynamin-3T-dynamindynamin family memberdynamin, testicular | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P14384 | Q9UQ16 | |
| Ensembl transtripts involved in fusion gene | ENST00000546373, ENST00000551568, ENST00000338356, ENST00000549691, | ENST00000358155, ENST00000367733, ENST00000355305, ENST00000367731, ENST00000520906, | |
| Fusion gene scores | * DoF score | 12 X 5 X 6=360 | 16 X 12 X 5=960 |
| # samples | 12 | 15 | |
| ** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CPM [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SG-A6Z7-01A | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000546373 | ENST00000358155 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000546373 | ENST00000367733 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000546373 | ENST00000355305 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000546373 | ENST00000367731 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000546373 | ENST00000520906 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| Frame-shift | ENST00000551568 | ENST00000358155 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000551568 | ENST00000367733 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000551568 | ENST00000355305 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000551568 | ENST00000367731 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000551568 | ENST00000520906 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| Frame-shift | ENST00000338356 | ENST00000358155 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000338356 | ENST00000367733 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000338356 | ENST00000355305 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000338356 | ENST00000367731 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| 5CDS-intron | ENST00000338356 | ENST00000520906 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| intron-3CDS | ENST00000549691 | ENST00000358155 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| intron-intron | ENST00000549691 | ENST00000367733 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| intron-intron | ENST00000549691 | ENST00000355305 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| intron-intron | ENST00000549691 | ENST00000367731 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
| intron-intron | ENST00000549691 | ENST00000520906 | CPM | chr12 | 69326458 | - | DNM3 | chr1 | 172277868 | + |
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FusionProtFeatures for CPM_DNM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPM | DNM3 |