|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8152 |
FusionGeneSummary for COX10_INPP5K |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COX10_INPP5K | Fusion gene ID: 8152 | Hgene | Tgene | Gene symbol | COX10 | INPP5K | Gene ID | 1352 | 51763 |
| Gene name | COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor | inositol polyphosphate-5-phosphatase K | |
| Synonyms | - | MDCCAID|PPS|SKIP | |
| Cytomap | 17p12 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protoheme IX farnesyltransferase, mitochondrialCOX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferasecytochrome c oxidase assembly homolog 10cytochrome c oxidase assembly proteincytochrome c oxidase subunit Xheme A: farnesy | inositol polyphosphate 5-phosphatase Kskeletal muscle and kidney-enriched inositol phosphatase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q12887 | Q9BT40 | |
| Ensembl transtripts involved in fusion gene | ENST00000261643, ENST00000536205, ENST00000537334, ENST00000429152, | ENST00000421807, ENST00000406424, ENST00000320345, ENST00000397335, ENST00000542125, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: COX10 [Title/Abstract] AND INPP5K [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | INPP5K | GO:0006469 | negative regulation of protein kinase activity | 12556481 |
| Tgene | INPP5K | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 12556481 |
| Tgene | INPP5K | GO:0010829 | negative regulation of glucose transmembrane transport | 12556481 |
| Tgene | INPP5K | GO:0016311 | dephosphorylation | 21712384 |
| Tgene | INPP5K | GO:0032869 | cellular response to insulin stimulus | 12556481 |
| Tgene | INPP5K | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 12556481 |
| Tgene | INPP5K | GO:0043407 | negative regulation of MAP kinase activity | 12556481 |
| Tgene | INPP5K | GO:0043922 | negative regulation by host of viral transcription | 18774950 |
| Tgene | INPP5K | GO:0045719 | negative regulation of glycogen biosynthetic process | 12556481 |
| Tgene | INPP5K | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate | 18774950 |
| Tgene | INPP5K | GO:0046627 | negative regulation of insulin receptor signaling pathway | 12556481 |
| Tgene | INPP5K | GO:0046855 | inositol phosphate dephosphorylation | 12536145 |
| Tgene | INPP5K | GO:0046856 | phosphatidylinositol dephosphorylation | 12536145|12556481 |
| Tgene | INPP5K | GO:0051497 | negative regulation of stress fiber assembly | 12556481 |
| Tgene | INPP5K | GO:0051898 | negative regulation of protein kinase B signaling | 12556481 |
| Tgene | INPP5K | GO:0051926 | negative regulation of calcium ion transport | 12556481 |
| Tgene | INPP5K | GO:0071356 | cellular response to tumor necrosis factor | 21712384 |
| Tgene | INPP5K | GO:0071364 | cellular response to epidermal growth factor stimulus | 21712384 |
| Tgene | INPP5K | GO:0090315 | negative regulation of protein targeting to membrane | 12556481 |
| Tgene | INPP5K | GO:0097178 | ruffle assembly | 12556481 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CHOL | TCGA-W5-AA31-01A | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261643 | ENST00000421807 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000261643 | ENST00000406424 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000261643 | ENST00000320345 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000261643 | ENST00000397335 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000261643 | ENST00000542125 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000536205 | ENST00000421807 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000536205 | ENST00000406424 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000536205 | ENST00000320345 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000536205 | ENST00000397335 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000536205 | ENST00000542125 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000537334 | ENST00000421807 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000537334 | ENST00000406424 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000537334 | ENST00000320345 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000537334 | ENST00000397335 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| In-frame | ENST00000537334 | ENST00000542125 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| intron-3CDS | ENST00000429152 | ENST00000421807 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| intron-3CDS | ENST00000429152 | ENST00000406424 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| intron-3CDS | ENST00000429152 | ENST00000320345 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| intron-3CDS | ENST00000429152 | ENST00000397335 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
| intron-3CDS | ENST00000429152 | ENST00000542125 | COX10 | chr17 | 14063264 | + | INPP5K | chr17 | 1401416 | - |
Top |
FusionProtFeatures for COX10_INPP5K |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COX10 | INPP5K |