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Fusion gene ID: 8103

FusionGeneSummary for COPS7B_PTMA

Fusion gene summary

Fusion gene information	Fusion gene name: COPS7B_PTMA
	Fusion gene ID: 8103
		Hgene	Tgene
	Gene symbol	COPS7B	PTMA
	Gene ID	64708	5757
	Gene name	COP9 signalosome subunit 7B	prothymosin alpha
	Synonyms	CSN7B\|SGN7b	TMSA
	Cytomap	2q37.1	2q37.1
	Type of gene	protein-coding	protein-coding
	Description	COP9 signalosome complex subunit 7bCOP9 constitutive photomorphogenic homolog subunit 7BJAB1-containing signalosome subunit 7bsignalosome subunit 7b	prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
	Modification date	20180523	20180522
	UniProtAcc	Q9H9Q2	P06454
	Ensembl transtripts involved in fusion gene	ENST00000410024, ENST00000409295, ENST00000409091, ENST00000350033, ENST00000410017, ENST00000373608,	ENST00000466801, ENST00000409321, ENST00000409115, ENST00000341369, ENST00000409683, ENST00000410064,
Fusion gene scores	* DoF score	4 X 5 X 2=40	17 X 17 X 2=578
	# samples	7	18
	** MAII score	log2(7/40*10)=0.807354922057604 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(18/578*10)=-1.683072586171 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: COPS7B [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COPS7B	GO:0000338	protein deneddylation	19141280

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PAAD	TCGA-FB-AAPZ-01A	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3UTR	ENST00000410024	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000410024	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000410024	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000410024	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000410024	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000410024	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5CDS-3UTR	ENST00000409295	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
5UTR-3UTR	ENST00000409091	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000350033	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000410017	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000466801	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000409321	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000409115	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000341369	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000409683	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+
intron-3UTR	ENST00000373608	ENST00000410064	COPS7B	chr2	232646593	+	PTMA	chr2	232576058	+

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FusionProtFeatures for COPS7B_PTMA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COPS7B Q9H9Q2	PTMA P06454

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Fusion gene ID: 8103

FusionGeneSummary for COPS7B_PTMA

FusionProtFeatures for COPS7B_PTMA