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Fusion gene ID: 8090 |
FusionGeneSummary for COPS4_NFXL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPS4_NFXL1 | Fusion gene ID: 8090 | Hgene | Tgene | Gene symbol | COPS4 | NFXL1 | Gene ID | 51138 | 152518 |
| Gene name | COP9 signalosome subunit 4 | nuclear transcription factor, X-box binding like 1 | |
| Synonyms | CSN4|SGN4 | CDZFP|HOZFP|OZFP|URCC5 | |
| Cytomap | 4q21.22 | 4p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | COP9 signalosome complex subunit 4COP9 constitutive photomorphogenic homolog subunit 4COP9 constitutive photomorphogenic-like protein subunit 4JAB1-containing signalosome subunit 4signalosome subunit 4testis tissue sperm-binding protein Li 42a | NF-X1-type zinc finger protein NFXL1cytoplasm-distribution zinc finger proteinovarian zinc finger proteinup-regulated in colon cancer 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BT78 | Q6ZNB6 | |
| Ensembl transtripts involved in fusion gene | ENST00000509093, ENST00000264389, ENST00000503682, ENST00000511653, ENST00000511708, | ENST00000381538, ENST00000507489, ENST00000329043, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COPS4 [Title/Abstract] AND NFXL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPS4 | GO:0000338 | protein deneddylation | 19141280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AZ-6601-01A | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000509093 | ENST00000381538 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000509093 | ENST00000507489 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000509093 | ENST00000329043 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000264389 | ENST00000381538 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000264389 | ENST00000507489 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000264389 | ENST00000329043 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000503682 | ENST00000381538 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000503682 | ENST00000507489 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000503682 | ENST00000329043 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000511653 | ENST00000381538 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000511653 | ENST00000507489 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| In-frame | ENST00000511653 | ENST00000329043 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| 3UTR-3CDS | ENST00000511708 | ENST00000381538 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| 3UTR-3CDS | ENST00000511708 | ENST00000507489 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
| 3UTR-3CDS | ENST00000511708 | ENST00000329043 | COPS4 | chr4 | 83966858 | + | NFXL1 | chr4 | 47888016 | - |
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FusionProtFeatures for COPS4_NFXL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPS4 | NFXL1 |