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Fusion gene ID: 8061 |
FusionGeneSummary for COPA_CISD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPA_CISD3 | Fusion gene ID: 8061 | Hgene | Tgene | Gene symbol | COPA | CISD3 | Gene ID | 1314 | 284106 |
| Gene name | coatomer protein complex subunit alpha | CDGSH iron sulfur domain 3 | |
| Synonyms | AILJK|HEP-COP | MiNT|Miner2 | |
| Cytomap | 1q23.2 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coatomer subunit alphaHEPCOPalpha coat proteinalpha-COPproxeninxenin | CDGSH iron-sulfur domain-containing protein 3, mitochondrialmitoNEET related 2mitoNEET-related protein 2mitochondrial inner NEET protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P53621 | P0C7P0 | |
| Ensembl transtripts involved in fusion gene | ENST00000368069, ENST00000241704, | ENST00000439660, ENST00000578573, | |
| Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 5 X 2 X 4=40 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COPA [Title/Abstract] AND CISD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPA | GO:0030157 | pancreatic juice secretion | 1429581 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A1EV-01A | COPA | chr1 | 160293221 | - | CISD3 | chr17 | 36887013 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000368069 | ENST00000439660 | COPA | chr1 | 160293221 | - | CISD3 | chr17 | 36887013 | + |
| 5CDS-3UTR | ENST00000368069 | ENST00000578573 | COPA | chr1 | 160293221 | - | CISD3 | chr17 | 36887013 | + |
| Frame-shift | ENST00000241704 | ENST00000439660 | COPA | chr1 | 160293221 | - | CISD3 | chr17 | 36887013 | + |
| 5CDS-3UTR | ENST00000241704 | ENST00000578573 | COPA | chr1 | 160293221 | - | CISD3 | chr17 | 36887013 | + |
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FusionProtFeatures for COPA_CISD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPA | CISD3 |