	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 8057

FusionGeneSummary for COMT_THBS3

Fusion gene summary

Fusion gene information	Fusion gene name: COMT_THBS3
	Fusion gene ID: 8057
		Hgene	Tgene
	Gene symbol	COMT	THBS3
	Gene ID	1312	7059
	Gene name	catechol-O-methyltransferase	thrombospondin 3
	Synonyms	HEL-S-98n	TSP3
	Cytomap	22q11.21	1q22
	Type of gene	protein-coding	protein-coding
	Description	catechol O-methyltransferasecatechol-O-methyltransferase isoformepididymis secretory sperm binding protein Li 98ntesticular tissue protein Li 42	thrombospondin-3
	Modification date	20180527	20180519
	UniProtAcc	P21964	P49746
	Ensembl transtripts involved in fusion gene	ENST00000361682, ENST00000403184, ENST00000403710, ENST00000407537, ENST00000406520, ENST00000449653, ENST00000493893,	ENST00000368378, ENST00000541576, ENST00000457183, ENST00000541990, ENST00000486260,
Fusion gene scores	* DoF score	9 X 8 X 4=288	6 X 6 X 2=72
	# samples	10	7
	** MAII score	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: COMT [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COMT	GO:0042424	catecholamine catabolic process	15645182\|21846718

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW340773	COMT	chr22	19957168	-	THBS3	chr1	155177604	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000361682	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000361682	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000361682	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-5UTR	ENST00000361682	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000361682	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-3CDS	ENST00000403184	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403184	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403184	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-5UTR	ENST00000403184	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403184	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-3CDS	ENST00000403710	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403710	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403710	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-5UTR	ENST00000403710	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000403710	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-3CDS	ENST00000407537	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000407537	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000407537	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-5UTR	ENST00000407537	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000407537	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-3CDS	ENST00000406520	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000406520	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000406520	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-5UTR	ENST00000406520	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000406520	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-3CDS	ENST00000449653	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000449653	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000449653	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-5UTR	ENST00000449653	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
3UTR-intron	ENST00000449653	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-3CDS	ENST00000493893	ENST00000368378	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000493893	ENST00000541576	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000493893	ENST00000457183	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-5UTR	ENST00000493893	ENST00000541990	COMT	chr22	19957168	-	THBS3	chr1	155177604	+
intron-intron	ENST00000493893	ENST00000486260	COMT	chr22	19957168	-	THBS3	chr1	155177604	+

Top

FusionProtFeatures for COMT_THBS3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COMT P21964	THBS3 P49746

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 8057

FusionGeneSummary for COMT_THBS3

FusionProtFeatures for COMT_THBS3