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Fusion gene ID: 8037 |
FusionGeneSummary for COMMD1_PAPOLG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COMMD1_PAPOLG | Fusion gene ID: 8037 | Hgene | Tgene | Gene symbol | COMMD1 | PAPOLG | Gene ID | 150684 | 64895 |
| Gene name | copper metabolism domain containing 1 | poly(A) polymerase gamma | |
| Synonyms | C2orf5|MURR1 | - | |
| Cytomap | 2p15 | 2p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | COMM domain-containing protein 1copper metabolism (Murr1) domain containing 1copper metabolism gene MURR1protein Murr1 | poly(A) polymerase gammaPAP-gammaSRP RNA 3' adenylating enzyme/pap2SRP RNA 3'-adenylating enzymeSRP RNA-adenylating enzymeneo-PAPneo-poly(A) polymerasenuclear poly(A) polymerase gammapolynucleotide adenylyltransferase gammasignal recognition part | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N668 | Q9BWT3 | |
| Ensembl transtripts involved in fusion gene | ENST00000472729, ENST00000311832, ENST00000538736, | ENST00000238714, ENST00000483370, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: COMMD1 [Title/Abstract] AND PAPOLG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COMMD1 | GO:0031398 | positive regulation of protein ubiquitination | 17183367|21741370 |
| Hgene | COMMD1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 15799966|16573520 |
| Hgene | COMMD1 | GO:0048227 | plasma membrane to endosome transport | 21741370 |
| Hgene | COMMD1 | GO:0055070 | copper ion homeostasis | 14685266 |
| Hgene | COMMD1 | GO:1902306 | negative regulation of sodium ion transmembrane transport | 14645214 |
| Hgene | COMMD1 | GO:2000009 | negative regulation of protein localization to cell surface | 21741370 |
| Tgene | PAPOLG | GO:0043631 | RNA polyadenylation | 11287430|11463842 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | DLBC | TCGA-RQ-A6JB-01A | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000472729 | ENST00000238714 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| intron-intron | ENST00000472729 | ENST00000483370 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| Frame-shift | ENST00000311832 | ENST00000238714 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| 5CDS-intron | ENST00000311832 | ENST00000483370 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| Frame-shift | ENST00000538736 | ENST00000238714 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
| 5CDS-intron | ENST00000538736 | ENST00000483370 | COMMD1 | chr2 | 62132993 | + | PAPOLG | chr2 | 60987269 | + |
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FusionProtFeatures for COMMD1_PAPOLG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COMMD1 | PAPOLG |