|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8027 |
FusionGeneSummary for COLGALT1_PGLS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COLGALT1_PGLS | Fusion gene ID: 8027 | Hgene | Tgene | Gene symbol | COLGALT1 | PGLS | Gene ID | 79709 | 25796 |
| Gene name | collagen beta(1-O)galactosyltransferase 1 | 6-phosphogluconolactonase | |
| Synonyms | ColGalT 1|GLT25D1 | 6PGL|HEL-S-304 | |
| Cytomap | 19p13.11 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | procollagen galactosyltransferase 1glycosyltransferase 25 domain containing 1glycosyltransferase 25 family member 1hydroxylysine galactosyltransferase 1 | 6-phosphogluconolactonaseepididymis secretory protein Li 304 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NBJ5 | O95336 | |
| Ensembl transtripts involved in fusion gene | ENST00000252599, ENST00000601354, | ENST00000252603, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: COLGALT1 [Title/Abstract] AND PGLS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PGLS | GO:0006098 | pentose-phosphate shunt | 10518023 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CQ-7067-01A | COLGALT1 | chr19 | 17670230 | + | PGLS | chr19 | 17626982 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000252599 | ENST00000252603 | COLGALT1 | chr19 | 17670230 | + | PGLS | chr19 | 17626982 | + |
| intron-3CDS | ENST00000601354 | ENST00000252603 | COLGALT1 | chr19 | 17670230 | + | PGLS | chr19 | 17626982 | + |
Top |
FusionProtFeatures for COLGALT1_PGLS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COLGALT1 | PGLS |