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Fusion gene ID: 7954 |
FusionGeneSummary for COL4A1_ZNF675 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL4A1_ZNF675 | Fusion gene ID: 7954 | Hgene | Tgene | Gene symbol | COL4A1 | ZNF675 | Gene ID | 1282 | 171392 |
| Gene name | collagen type IV alpha 1 chain | zinc finger protein 675 | |
| Synonyms | BSVD|RATOR | TBZF|TIZ | |
| Cytomap | 13q34 | 19p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-1(IV) chainCOL4A1 NC1 domainarrestencollagen IV, alpha-1 polypeptidecollagen of basement membrane, alpha-1 chain | zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P02462 | Q8TD23 | |
| Ensembl transtripts involved in fusion gene | ENST00000375820, ENST00000543140, ENST00000467182, | ENST00000601935, ENST00000600313, ENST00000596211, ENST00000359788, ENST00000601010, ENST00000599168, | |
| Fusion gene scores | * DoF score | 7 X 9 X 5=315 | 3 X 2 X 3=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COL4A1 [Title/Abstract] AND ZNF675 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZNF675 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11751921 |
| Tgene | ZNF675 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 11751921 |
| Tgene | ZNF675 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 11751921 |
| Tgene | ZNF675 | GO:0019221 | cytokine-mediated signaling pathway | 11751921 |
| Tgene | ZNF675 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11751921 |
| Tgene | ZNF675 | GO:0043508 | negative regulation of JUN kinase activity | 11751921 |
| Tgene | ZNF675 | GO:0045671 | negative regulation of osteoclast differentiation | 11751921|11851921 |
| Tgene | ZNF675 | GO:0046329 | negative regulation of JNK cascade | 11751921 |
| Tgene | ZNF675 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 11751921 |
| Tgene | ZNF675 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 11751921 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-2J-AABP-01A | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375820 | ENST00000601935 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000375820 | ENST00000600313 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000375820 | ENST00000596211 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000375820 | ENST00000359788 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000375820 | ENST00000601010 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000375820 | ENST00000599168 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000601935 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000600313 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000596211 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000359788 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000601010 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| In-frame | ENST00000543140 | ENST00000599168 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000601935 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000600313 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000596211 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000359788 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000601010 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
| intron-3CDS | ENST00000467182 | ENST00000599168 | COL4A1 | chr13 | 110959291 | - | ZNF675 | chr19 | 23845960 | - |
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FusionProtFeatures for COL4A1_ZNF675 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL4A1 | ZNF675 |