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Fusion gene ID: 7884 |
FusionGeneSummary for COL1A1_TCF25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL1A1_TCF25 | Fusion gene ID: 7884 | Hgene | Tgene | Gene symbol | COL1A1 | TCF25 | Gene ID | 1277 | 22980 |
| Gene name | collagen type I alpha 1 chain | transcription factor 25 | |
| Synonyms | EDSARTH1|EDSC|OI1|OI2|OI3|OI4 | FKSG26|Hulp1|NULP1|PRO2620|hKIAA1049 | |
| Cytomap | 17q21.33 | 16q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-1(I) chainalpha-1 type I collagenalpha1(I) procollagencollagen alpha 1 chain type Icollagen alpha-1(I) chain preproproteincollagen of skin, tendon and bone, alpha-1 chaincollagen, type I, alpha 1pro-alpha-1 collagen type 1type I pro | transcription factor 25TCF-25nuclear localized protein 1transcription factor 25 (basic helix-loop-helix) | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P02452 | Q9BQ70 | |
| Ensembl transtripts involved in fusion gene | ENST00000225964, | ENST00000263346, ENST00000563406, ENST00000263347, | |
| Fusion gene scores | * DoF score | 28 X 47 X 4=5264 | 5 X 6 X 3=90 |
| # samples | 52 | 13 | |
| ** MAII score | log2(52/5264*10)=-3.33957596070679 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/90*10)=0.53051471669878 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COL1A1 [Title/Abstract] AND TCF25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COL1A1 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 20018240 |
| Hgene | COL1A1 | GO:0030335 | positive regulation of cell migration | 20018240 |
| Hgene | COL1A1 | GO:0034504 | protein localization to nucleus | 20018240 |
| Hgene | COL1A1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20018240 |
| Hgene | COL1A1 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 20018240 |
| Tgene | TCF25 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16574069 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA063543 | COL1A1 | chr17 | 48261589 | + | TCF25 | chr16 | 89951048 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000225964 | ENST00000263346 | COL1A1 | chr17 | 48261589 | + | TCF25 | chr16 | 89951048 | - |
| intron-intron | ENST00000225964 | ENST00000563406 | COL1A1 | chr17 | 48261589 | + | TCF25 | chr16 | 89951048 | - |
| intron-intron | ENST00000225964 | ENST00000263347 | COL1A1 | chr17 | 48261589 | + | TCF25 | chr16 | 89951048 | - |
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FusionProtFeatures for COL1A1_TCF25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL1A1 | TCF25 |