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Fusion gene ID: 7856 |
FusionGeneSummary for COL18A1_COL18A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL18A1_COL18A1 | Fusion gene ID: 7856 | Hgene | Tgene | Gene symbol | COL18A1 | COL18A1 | Gene ID | 80781 | 80781 |
| Gene name | collagen type XVIII alpha 1 chain | collagen type XVIII alpha 1 chain | |
| Synonyms | KNO|KNO1|KS | KNO|KNO1|KS | |
| Cytomap | 21q22.3 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-1(XVIII) chainantiangiogenic agentcollagen alpha-1(XVIII) chain isoform 1 preproproteincollagen, type XVIII, alpha 1endostatinmulti-functional protein MFP | collagen alpha-1(XVIII) chainantiangiogenic agentcollagen alpha-1(XVIII) chain isoform 1 preproproteincollagen, type XVIII, alpha 1endostatinmulti-functional protein MFP | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P39060 | P39060 | |
| Ensembl transtripts involved in fusion gene | ENST00000400337, ENST00000355480, ENST00000359759, ENST00000459895, | ENST00000400337, ENST00000355480, ENST00000359759, ENST00000459895, | |
| Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 4 X 3 X 3=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COL18A1 [Title/Abstract] AND COL18A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W07798 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000400337 | ENST00000400337 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000400337 | ENST00000355480 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000400337 | ENST00000359759 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-intron | ENST00000400337 | ENST00000459895 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000355480 | ENST00000400337 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000355480 | ENST00000355480 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000355480 | ENST00000359759 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-intron | ENST00000355480 | ENST00000459895 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000359759 | ENST00000400337 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000359759 | ENST00000355480 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-3CDS | ENST00000359759 | ENST00000359759 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| 3UTR-intron | ENST00000359759 | ENST00000459895 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| intron-3CDS | ENST00000459895 | ENST00000400337 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| intron-3CDS | ENST00000459895 | ENST00000355480 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| intron-3CDS | ENST00000459895 | ENST00000359759 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
| intron-intron | ENST00000459895 | ENST00000459895 | COL18A1 | chr21 | 46933352 | + | COL18A1 | chr21 | 46925294 | + |
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FusionProtFeatures for COL18A1_COL18A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL18A1 | COL18A1 |