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Fusion gene ID: 7851 |
FusionGeneSummary for COL16A1_EXOC6B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL16A1_EXOC6B | Fusion gene ID: 7851 | Hgene | Tgene | Gene symbol | COL16A1 | EXOC6B | Gene ID | 1307 | 23233 |
| Gene name | collagen type XVI alpha 1 chain | exocyst complex component 6B | |
| Synonyms | 447AA|FP1572 | SEC15B|SEC15L2 | |
| Cytomap | 1p35.2 | 2p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-1(XVI) chainalpha 1 type XVI collagencollagen XVI, alpha-1 polypeptidecollagen, type XVI, alpha 1 | exocyst complex component 6BSEC15 homolog BSEC15-like protein 2exocyst complex component Sec15B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q07092 | Q9Y2D4 | |
| Ensembl transtripts involved in fusion gene | ENST00000271069, ENST00000373672, ENST00000461217, ENST00000373668, | ENST00000272427, ENST00000490919, ENST00000410104, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 8 X 7 X 4=224 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COL16A1 [Title/Abstract] AND EXOC6B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COL16A1 | GO:0007155 | cell adhesion | 16754661 |
| Hgene | COL16A1 | GO:0033622 | integrin activation | 16754661 |
| Hgene | COL16A1 | GO:0033627 | cell adhesion mediated by integrin | 16754661 |
| Hgene | COL16A1 | GO:0051894 | positive regulation of focal adhesion assembly | 24466237 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW444528 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000271069 | ENST00000272427 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000271069 | ENST00000490919 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000271069 | ENST00000410104 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373672 | ENST00000272427 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373672 | ENST00000490919 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373672 | ENST00000410104 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000461217 | ENST00000272427 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000461217 | ENST00000490919 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000461217 | ENST00000410104 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373668 | ENST00000272427 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373668 | ENST00000490919 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
| intron-intron | ENST00000373668 | ENST00000410104 | COL16A1 | chr1 | 32148821 | + | EXOC6B | chr2 | 72617870 | + |
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FusionProtFeatures for COL16A1_EXOC6B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL16A1 | EXOC6B |