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Fusion gene ID: 7805

FusionGeneSummary for COBL_COBL

Fusion gene summary

Fusion gene information	Fusion gene name: COBL_COBL
	Fusion gene ID: 7805
		Hgene	Tgene
	Gene symbol	COBL	COBL
	Gene ID	23242	23242
	Gene name	cordon-bleu WH2 repeat protein	cordon-bleu WH2 repeat protein
	Synonyms	-	-
	Cytomap	7p12.1	7p12.1
	Type of gene	protein-coding	protein-coding
	Description	protein cordon-bleu	protein cordon-bleu
	Modification date	20180519	20180519
	UniProtAcc	O75128	O75128
	Ensembl transtripts involved in fusion gene	ENST00000265136, ENST00000395542, ENST00000395540, ENST00000441453,	ENST00000265136, ENST00000395542, ENST00000395540, ENST00000441453,
Fusion gene scores	* DoF score	4 X 4 X 3=48	2 X 2 X 2=8
	# samples	5	3
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/8*10)=1.90689059560852
Context	PubMed: COBL [Title/Abstract] AND COBL [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW590697	COBL	chr7	51357167	+	COBL	chr7	51299873	+
ChiTaRS3.1			AW295178	COBL	chr7	51357167	+	COBL	chr7	51299873	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000265136	ENST00000265136	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000265136	ENST00000395542	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000265136	ENST00000395540	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000265136	ENST00000441453	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395542	ENST00000265136	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395542	ENST00000395542	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395542	ENST00000395540	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395542	ENST00000441453	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395540	ENST00000265136	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395540	ENST00000395542	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395540	ENST00000395540	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000395540	ENST00000441453	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000441453	ENST00000265136	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000441453	ENST00000395542	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000441453	ENST00000395540	COBL	chr7	51357167	+	COBL	chr7	51299873	+
intron-intron	ENST00000441453	ENST00000441453	COBL	chr7	51357167	+	COBL	chr7	51299873	+

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FusionProtFeatures for COBL_COBL

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COBL O75128	COBL O75128

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Fusion gene ID: 7805

FusionGeneSummary for COBL_COBL

FusionProtFeatures for COBL_COBL