|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7793 |
FusionGeneSummary for COA6_SLC35F3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COA6_SLC35F3 | Fusion gene ID: 7793 | Hgene | Tgene | Gene symbol | COA6 | SLC35F3 | Gene ID | 388753 | 148641 |
| Gene name | cytochrome c oxidase assembly factor 6 | solute carrier family 35 member F3 | |
| Synonyms | C1orf31|CEMCOX4 | - | |
| Cytomap | 1q42.2 | 1q42.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome c oxidase assembly factor 6 homolog | putative thiamine transporter SLC35F3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q5JTJ3 | Q8IY50 | |
| Ensembl transtripts involved in fusion gene | ENST00000366615, ENST00000366613, ENST00000366612, | ENST00000366618, ENST00000366617, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: COA6 [Title/Abstract] AND SLC35F3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COA6 | GO:0008535 | respiratory chain complex IV assembly | 25959673|26160915 |
| Tgene | SLC35F3 | GO:0015888 | thiamine transport | 24509276 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1487-01A | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366615 | ENST00000366618 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| Frame-shift | ENST00000366615 | ENST00000366617 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| Frame-shift | ENST00000366613 | ENST00000366618 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| Frame-shift | ENST00000366613 | ENST00000366617 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| Frame-shift | ENST00000366612 | ENST00000366618 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
| Frame-shift | ENST00000366612 | ENST00000366617 | COA6 | chr1 | 234510135 | + | SLC35F3 | chr1 | 234444847 | + |
Top |
FusionProtFeatures for COA6_SLC35F3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COA6 | SLC35F3 |