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Fusion gene ID: 7719 |
FusionGeneSummary for CNOT2_SLCO1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT2_SLCO1A2 | Fusion gene ID: 7719 | Hgene | Tgene | Gene symbol | CNOT2 | SLCO1A2 | Gene ID | 4848 | 6579 |
| Gene name | CCR4-NOT transcription complex subunit 2 | solute carrier organic anion transporter family member 1A2 | |
| Synonyms | CDC36|HSPC131|NOT2|NOT2H | OATP|OATP-A|OATP1A2|SLC21A3 | |
| Cytomap | 12q15 | 12p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | solute carrier organic anion transporter family member 1A2OATP-1organic anion transporting polypeptide Aorganic anion-transporting polypeptide 1sodium-independent organic anion transportersolute carrier family 21 (organic anion transporter), member 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NZN8 | P46721 | |
| Ensembl transtripts involved in fusion gene | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | ENST00000307378, ENST00000537524, ENST00000473830, ENST00000452078, ENST00000458504, ENST00000390670, | |
| Fusion gene scores | * DoF score | 26 X 8 X 9=1872 | 8 X 6 X 6=288 |
| # samples | 25 | 8 | |
| ** MAII score | log2(25/1872*10)=-2.90458043492132 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNOT2 [Title/Abstract] AND SLCO1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TQ-A7RH-01A | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000229195 | ENST00000307378 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| In-frame | ENST00000229195 | ENST00000537524 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000229195 | ENST00000473830 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000229195 | ENST00000452078 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000229195 | ENST00000458504 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000229195 | ENST00000390670 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| In-frame | ENST00000418359 | ENST00000307378 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| In-frame | ENST00000418359 | ENST00000537524 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000418359 | ENST00000473830 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000418359 | ENST00000452078 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000418359 | ENST00000458504 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| 5CDS-intron | ENST00000418359 | ENST00000390670 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-3CDS | ENST00000548230 | ENST00000307378 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-3CDS | ENST00000548230 | ENST00000537524 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000548230 | ENST00000473830 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000548230 | ENST00000452078 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000548230 | ENST00000458504 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000548230 | ENST00000390670 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-3CDS | ENST00000551483 | ENST00000307378 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-3CDS | ENST00000551483 | ENST00000537524 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000551483 | ENST00000473830 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000551483 | ENST00000452078 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000551483 | ENST00000458504 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
| intron-intron | ENST00000551483 | ENST00000390670 | CNOT2 | chr12 | 70672054 | + | SLCO1A2 | chr12 | 21445270 | - |
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FusionProtFeatures for CNOT2_SLCO1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT2 | SLCO1A2 |