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Fusion gene ID: 7713 |
FusionGeneSummary for CNOT2_NUP107 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT2_NUP107 | Fusion gene ID: 7713 | Hgene | Tgene | Gene symbol | CNOT2 | NUP107 | Gene ID | 4848 | 57122 |
| Gene name | CCR4-NOT transcription complex subunit 2 | nucleoporin 107 | |
| Synonyms | CDC36|HSPC131|NOT2|NOT2H | NPHS11|NUP84 | |
| Cytomap | 12q15 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | nuclear pore complex protein Nup107nucleoporin 107kDa | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NZN8 | P57740 | |
| Ensembl transtripts involved in fusion gene | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | ENST00000229179, ENST00000378905, ENST00000539906, ENST00000401003, | |
| Fusion gene scores | * DoF score | 26 X 8 X 9=1872 | 23 X 12 X 9=2484 |
| # samples | 25 | 26 | |
| ** MAII score | log2(25/1872*10)=-2.90458043492132 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/2484*10)=-3.25608164519203 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNOT2 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Tgene | NUP107 | GO:0006406 | mRNA export from nucleus | 11684705 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A08F-01A | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| TCGA | RV | STAD | TCGA-FP-7998-01A | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000229195 | ENST00000229179 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-5UTR | ENST00000229195 | ENST00000378905 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-5UTR | ENST00000229195 | ENST00000539906 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-intron | ENST00000229195 | ENST00000401003 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-3CDS | ENST00000418359 | ENST00000229179 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-5UTR | ENST00000418359 | ENST00000378905 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-5UTR | ENST00000418359 | ENST00000539906 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| 5UTR-intron | ENST00000418359 | ENST00000401003 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-3CDS | ENST00000548230 | ENST00000229179 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-5UTR | ENST00000548230 | ENST00000378905 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-5UTR | ENST00000548230 | ENST00000539906 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-intron | ENST00000548230 | ENST00000401003 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-3CDS | ENST00000551483 | ENST00000229179 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-5UTR | ENST00000551483 | ENST00000378905 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-5UTR | ENST00000551483 | ENST00000539906 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| intron-intron | ENST00000551483 | ENST00000401003 | CNOT2 | chr12 | 70637260 | + | NUP107 | chr12 | 69090599 | + |
| In-frame | ENST00000229195 | ENST00000229179 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-5UTR | ENST00000229195 | ENST00000378905 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-5UTR | ENST00000229195 | ENST00000539906 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-intron | ENST00000229195 | ENST00000401003 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| In-frame | ENST00000418359 | ENST00000229179 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-5UTR | ENST00000418359 | ENST00000378905 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-5UTR | ENST00000418359 | ENST00000539906 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 5CDS-intron | ENST00000418359 | ENST00000401003 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 3UTR-3CDS | ENST00000548230 | ENST00000229179 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 3UTR-5UTR | ENST00000548230 | ENST00000378905 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 3UTR-5UTR | ENST00000548230 | ENST00000539906 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| 3UTR-intron | ENST00000548230 | ENST00000401003 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| intron-3CDS | ENST00000551483 | ENST00000229179 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| intron-5UTR | ENST00000551483 | ENST00000378905 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| intron-5UTR | ENST00000551483 | ENST00000539906 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
| intron-intron | ENST00000551483 | ENST00000401003 | CNOT2 | chr12 | 70724249 | + | NUP107 | chr12 | 69082742 | + |
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FusionProtFeatures for CNOT2_NUP107 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT2 | NUP107 |