|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7694 |
FusionGeneSummary for CNOT1_GOT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT1_GOT2 | Fusion gene ID: 7694 | Hgene | Tgene | Gene symbol | CNOT1 | GOT2 | Gene ID | 23019 | 2806 |
| Gene name | CCR4-NOT transcription complex subunit 1 | glutamic-oxaloacetic transaminase 2 | |
| Synonyms | AD-005|CDC39|NOT1|NOT1H | KAT4|KATIV|KYAT4|mitAAT | |
| Cytomap | 16q21 | 16q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog | aspartate aminotransferase, mitochondrialFABP-1FABPpmaspartate aminotransferase 2aspartate transaminase 2fatty acid-binding proteinglutamate oxaloacetate transaminase 2glutamic-oxaloacetic transaminase 2, mitochondrialkynurenine aminotransferase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A5YKK6 | P00505 | |
| Ensembl transtripts involved in fusion gene | ENST00000317147, ENST00000569240, ENST00000441024, ENST00000569732, ENST00000245138, | ENST00000245206, ENST00000434819, ENST00000564400, | |
| Fusion gene scores | * DoF score | 14 X 9 X 10=1260 | 4 X 4 X 3=48 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CNOT1 [Title/Abstract] AND GOT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16778766 |
| Hgene | CNOT1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly | 21976065 |
| Hgene | CNOT1 | GO:0017148 | negative regulation of translation | 24736845 |
| Hgene | CNOT1 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 16778766 |
| Hgene | CNOT1 | GO:0035195 | gene silencing by miRNA | 23172285|24768540 |
| Hgene | CNOT1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 16778766 |
| Hgene | CNOT1 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 23644599 |
| Tgene | GOT2 | GO:0006533 | aspartate catabolic process | 2567216 |
| Tgene | GOT2 | GO:0045471 | response to ethanol | 9537447 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-E7-A85H-01A | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| TCGA | RV | LUSC | TCGA-98-A539-01A | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000317147 | ENST00000245206 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| In-frame | ENST00000317147 | ENST00000434819 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| 5CDS-5UTR | ENST00000317147 | ENST00000564400 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| In-frame | ENST00000569240 | ENST00000245206 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| In-frame | ENST00000569240 | ENST00000434819 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| 5CDS-5UTR | ENST00000569240 | ENST00000564400 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| In-frame | ENST00000441024 | ENST00000245206 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| In-frame | ENST00000441024 | ENST00000434819 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| 5CDS-5UTR | ENST00000441024 | ENST00000564400 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000569732 | ENST00000245206 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000569732 | ENST00000434819 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-5UTR | ENST00000569732 | ENST00000564400 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000245138 | ENST00000245206 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000245138 | ENST00000434819 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| intron-5UTR | ENST00000245138 | ENST00000564400 | CNOT1 | chr16 | 58608513 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000317147 | ENST00000245206 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000317147 | ENST00000434819 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-5UTR | ENST00000317147 | ENST00000564400 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000569240 | ENST00000245206 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000569240 | ENST00000434819 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-5UTR | ENST00000569240 | ENST00000564400 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000441024 | ENST00000245206 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-3CDS | ENST00000441024 | ENST00000434819 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| 5UTR-5UTR | ENST00000441024 | ENST00000564400 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000569732 | ENST00000245206 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000569732 | ENST00000434819 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-5UTR | ENST00000569732 | ENST00000564400 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000245138 | ENST00000245206 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-3CDS | ENST00000245138 | ENST00000434819 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
| intron-5UTR | ENST00000245138 | ENST00000564400 | CNOT1 | chr16 | 58663632 | - | GOT2 | chr16 | 58757806 | - |
Top |
FusionProtFeatures for CNOT1_GOT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT1 | GOT2 |