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Fusion gene ID: 7676 |
FusionGeneSummary for CNN2_SSU72 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNN2_SSU72 | Fusion gene ID: 7676 | Hgene | Tgene | Gene symbol | CNN2 | SSU72 | Gene ID | 1265 | 29101 |
| Gene name | calponin 2 | SSU72 homolog, RNA polymerase II CTD phosphatase | |
| Synonyms | - | HSPC182|PNAS-120 | |
| Cytomap | 19p13.3 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calponin-2calponin H2, smooth muscleneutral calponin | RNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q99439 | Q9NP77 | |
| Ensembl transtripts involved in fusion gene | ENST00000263097, ENST00000606983, ENST00000348419, ENST00000565096, ENST00000562958, | ENST00000291386, ENST00000359060, | |
| Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 9 X 7 X 6=378 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNN2 [Title/Abstract] AND SSU72 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNN2 | GO:0032970 | regulation of actin filament-based process | 16236705 |
| Hgene | CNN2 | GO:0071260 | cellular response to mechanical stimulus | 16236705 |
| Tgene | SSU72 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain | 20861839 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB278470 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263097 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000263097 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| 3UTR-3CDS | ENST00000606983 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| 3UTR-3CDS | ENST00000606983 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| Frame-shift | ENST00000348419 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000348419 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| intron-3CDS | ENST00000565096 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| intron-3CDS | ENST00000565096 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| Frame-shift | ENST00000562958 | ENST00000291386 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
| In-frame | ENST00000562958 | ENST00000359060 | CNN2 | chr19 | 1032695 | + | SSU72 | chr1 | 1500298 | - |
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FusionProtFeatures for CNN2_SSU72 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNN2 | SSU72 |