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Fusion gene ID: 7619 |
FusionGeneSummary for CMTM6_EPHB4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CMTM6_EPHB4 | Fusion gene ID: 7619 | Hgene | Tgene | Gene symbol | CMTM6 | EPHB4 | Gene ID | 54918 | 2050 |
| Gene name | CKLF like MARVEL transmembrane domain containing 6 | EPH receptor B4 | |
| Synonyms | CKLFSF6|PRO2219 | HFASD|HTK|MYK1|TYRO11 | |
| Cytomap | 3p22.3 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CKLF-like MARVEL transmembrane domain-containing protein 6chemokine-like factor super family 6chemokine-like factor superfamily 6chemokine-like factor superfamily member 6 | ephrin type-B receptor 4ephrin receptor EphB4hepatoma transmembrane kinasesoluble EPHB4 variant 1soluble EPHB4 variant 2soluble EPHB4 variant 3tyrosine-protein kinase TYRO11tyrosine-protein kinase receptor HTK | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NX76 | P54760 | |
| Ensembl transtripts involved in fusion gene | ENST00000205636, | ENST00000360620, ENST00000358173, ENST00000477446, | |
| Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CMTM6 [Title/Abstract] AND EPHB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EPHB4 | GO:0002042 | cell migration involved in sprouting angiogenesis | 12734395 |
| Tgene | EPHB4 | GO:0007155 | cell adhesion | 12734395 |
| Tgene | EPHB4 | GO:0046777 | protein autophosphorylation | 8188704 |
| Tgene | EPHB4 | GO:0048013 | ephrin receptor signaling pathway | 12734395 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW579301 | CMTM6 | chr3 | 32523472 | + | EPHB4 | chr7 | 100400632 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000205636 | ENST00000360620 | CMTM6 | chr3 | 32523472 | + | EPHB4 | chr7 | 100400632 | + |
| intron-3UTR | ENST00000205636 | ENST00000358173 | CMTM6 | chr3 | 32523472 | + | EPHB4 | chr7 | 100400632 | + |
| intron-intron | ENST00000205636 | ENST00000477446 | CMTM6 | chr3 | 32523472 | + | EPHB4 | chr7 | 100400632 | + |
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FusionProtFeatures for CMTM6_EPHB4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CMTM6 | EPHB4 |