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Fusion gene ID: 7611 |
FusionGeneSummary for CMTM4_CMTM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CMTM4_CMTM3 | Fusion gene ID: 7611 | Hgene | Tgene | Gene symbol | CMTM4 | CMTM3 | Gene ID | 146223 | 123920 |
| Gene name | CKLF like MARVEL transmembrane domain containing 4 | CKLF like MARVEL transmembrane domain containing 3 | |
| Synonyms | CKLFSF4 | BNAS2|CKLFSF3 | |
| Cytomap | 16q21-q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4 | CKLF-like MARVEL transmembrane domain-containing protein 3chemokine-like factor superfamily member 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IZR5 | Q96MX0 | |
| Ensembl transtripts involved in fusion gene | ENST00000330687, ENST00000394106, ENST00000563952, | ENST00000424011, ENST00000360086, ENST00000562707, ENST00000361909, ENST00000460097, ENST00000565666, ENST00000567572, ENST00000564060, ENST00000565922, ENST00000565003, ENST00000568477, ENST00000566121, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CMTM4 [Title/Abstract] AND CMTM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8077-01A | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000330687 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000330687 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000330687 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000330687 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000330687 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000330687 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| In-frame | ENST00000394106 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000394106 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000394106 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000394106 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-intron | ENST00000394106 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| 5CDS-5UTR | ENST00000394106 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-3CDS | ENST00000563952 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-intron | ENST00000563952 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-intron | ENST00000563952 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-intron | ENST00000563952 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-intron | ENST00000563952 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
| intron-5UTR | ENST00000563952 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
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FusionProtFeatures for CMTM4_CMTM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CMTM4 | CMTM3 |