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Fusion gene ID: 7560 |
FusionGeneSummary for CLU_MYH9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLU_MYH9 | Fusion gene ID: 7560 | Hgene | Tgene | Gene symbol | CLU | MYH9 | Gene ID | 1191 | 4627 |
| Gene name | clusterin | myosin heavy chain 9 | |
| Synonyms | AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2 | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA | |
| Cytomap | 8p21.1 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40ku70-binding protein 1sulfated glycoprotein 2testosterone-repressed prostate message 2 | myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P10909 | P35579 | |
| Ensembl transtripts involved in fusion gene | ENST00000316403, ENST00000546343, ENST00000560366, ENST00000405140, ENST00000523500, | ENST00000216181, ENST00000475726, ENST00000401701, | |
| Fusion gene scores | * DoF score | 24 X 23 X 8=4416 | 23 X 25 X 7=4025 |
| # samples | 30 | 28 | |
| ** MAII score | log2(30/4416*10)=-3.87970576628229 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/4025*10)=-3.84549005094438 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLU [Title/Abstract] AND MYH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLU | GO:0000902 | cell morphogenesis | 15857407 |
| Hgene | CLU | GO:0001774 | microglial cell activation | 15857407 |
| Hgene | CLU | GO:0017038 | protein import | 24446231 |
| Hgene | CLU | GO:0032463 | negative regulation of protein homooligomerization | 22179788|23106396 |
| Hgene | CLU | GO:0032464 | positive regulation of protein homooligomerization | 22179788 |
| Hgene | CLU | GO:0032760 | positive regulation of tumor necrosis factor production | 15857407 |
| Hgene | CLU | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 15857407 |
| Hgene | CLU | GO:0050821 | protein stabilization | 11123922 |
| Hgene | CLU | GO:0051131 | chaperone-mediated protein complex assembly | 17412999 |
| Hgene | CLU | GO:0051788 | response to misfolded protein | 19996109 |
| Hgene | CLU | GO:0061077 | chaperone-mediated protein folding | 11123922 |
| Hgene | CLU | GO:0061518 | microglial cell proliferation | 15857407 |
| Hgene | CLU | GO:1900221 | regulation of amyloid-beta clearance | 24446231 |
| Hgene | CLU | GO:1901214 | regulation of neuron death | 17412999 |
| Hgene | CLU | GO:1901216 | positive regulation of neuron death | 15857407 |
| Hgene | CLU | GO:1902430 | negative regulation of amyloid-beta formation | 12047389|17412999 |
| Hgene | CLU | GO:1905907 | negative regulation of amyloid fibril formation | 22179788 |
| Tgene | MYH9 | GO:0001525 | angiogenesis | 16403913 |
| Tgene | MYH9 | GO:0006509 | membrane protein ectodomain proteolysis | 16186248 |
| Tgene | MYH9 | GO:0030048 | actin filament-based movement | 12237319|15845534 |
| Tgene | MYH9 | GO:0031032 | actomyosin structure organization | 24072716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-UY-A9PE-01A | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000316403 | ENST00000216181 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000316403 | ENST00000475726 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000316403 | ENST00000401701 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| Frame-shift | ENST00000546343 | ENST00000216181 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000546343 | ENST00000475726 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000546343 | ENST00000401701 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| Frame-shift | ENST00000560366 | ENST00000216181 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000560366 | ENST00000475726 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000560366 | ENST00000401701 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| In-frame | ENST00000405140 | ENST00000216181 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000405140 | ENST00000475726 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000405140 | ENST00000401701 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| Frame-shift | ENST00000523500 | ENST00000216181 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000523500 | ENST00000475726 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
| 5CDS-intron | ENST00000523500 | ENST00000401701 | CLU | chr8 | 27463871 | - | MYH9 | chr22 | 36723533 | - |
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FusionProtFeatures for CLU_MYH9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLU | MYH9 |