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Fusion gene ID: 7543 |
FusionGeneSummary for CLTC_ROS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLTC_ROS1 | Fusion gene ID: 7543 | Hgene | Tgene | Gene symbol | CLTC | ROS1 | Gene ID | 1213 | 6098 |
| Gene name | clathrin heavy chain | ROS proto-oncogene 1, receptor tyrosine kinase | |
| Synonyms | CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56 | MCF3|ROS|c-ros-1 | |
| Cytomap | 17q23.1 | 6q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2 | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00610 | P08922 | |
| Ensembl transtripts involved in fusion gene | ENST00000393043, ENST00000269122, ENST00000579456, ENST00000579815, | ENST00000368508, ENST00000368507, | |
| Fusion gene scores | * DoF score | 14 X 8 X 8=896 | 5 X 6 X 3=90 |
| # samples | 14 | 12 | |
| ** MAII score | log2(14/896*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/90*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLTC [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLTC | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 24251095 |
| Tgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
| Tgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
| Tgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-2665-01A | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000393043 | ENST00000368508 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| Frame-shift | ENST00000393043 | ENST00000368507 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000269122 | ENST00000368508 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000269122 | ENST00000368507 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000579456 | ENST00000368508 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| In-frame | ENST00000579456 | ENST00000368507 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| intron-3CDS | ENST00000579815 | ENST00000368508 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
| intron-3CDS | ENST00000579815 | ENST00000368507 | CLTC | chr17 | 57768072 | + | ROS1 | chr6 | 117642557 | - |
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FusionProtFeatures for CLTC_ROS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLTC | ROS1 |