|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7527 |
FusionGeneSummary for CLTB_PSMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLTB_PSMF1 | Fusion gene ID: 7527 | Hgene | Tgene | Gene symbol | CLTB | PSMF1 | Gene ID | 1212 | 9491 |
| Gene name | clathrin light chain B | proteasome inhibitor subunit 1 | |
| Synonyms | LCB | PI31 | |
| Cytomap | 5q35.2 | 20p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | clathrin light chain Bclathrin, light chain (Lcb)clathrin, light polypeptide (Lcb) | proteasome inhibitor PI31 subunitproteasome (prosome, macropain) inhibitor subunit 1 (PI31) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P09497 | Q92530 | |
| Ensembl transtripts involved in fusion gene | ENST00000345807, ENST00000310418, ENST00000509319, | ENST00000381898, ENST00000333082, ENST00000246015, ENST00000335877, ENST00000438768, ENST00000484891, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 5 X 3=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLTB [Title/Abstract] AND PSMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PSMF1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 10764772 |
| Tgene | PSMF1 | GO:1901799 | negative regulation of proteasomal protein catabolic process | 10764772 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW170550 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000345807 | ENST00000381898 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000345807 | ENST00000333082 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000345807 | ENST00000246015 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000345807 | ENST00000335877 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000345807 | ENST00000438768 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-3UTR | ENST00000345807 | ENST00000484891 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000310418 | ENST00000381898 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000310418 | ENST00000333082 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000310418 | ENST00000246015 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000310418 | ENST00000335877 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000310418 | ENST00000438768 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-3UTR | ENST00000310418 | ENST00000484891 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000509319 | ENST00000381898 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000509319 | ENST00000333082 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000509319 | ENST00000246015 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000509319 | ENST00000335877 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-intron | ENST00000509319 | ENST00000438768 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
| intron-3UTR | ENST00000509319 | ENST00000484891 | CLTB | chr5 | 175843360 | + | PSMF1 | chr20 | 1145721 | - |
Top |
FusionProtFeatures for CLTB_PSMF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLTB | PSMF1 |