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Fusion gene ID: 7506

FusionGeneSummary for CLSTN1_SLC7A2

Fusion gene summary

Fusion gene information	Fusion gene name: CLSTN1_SLC7A2
	Fusion gene ID: 7506
		Hgene	Tgene
	Gene symbol	CLSTN1	SLC7A2
	Gene ID	22883	6542
	Gene name	calsyntenin 1	solute carrier family 7 member 2
	Synonyms	ALC-ALPHA\|CDHR12\|CST-1\|CSTN1\|PIK3CD\|XB31alpha\|alcalpha1\|alcalpha2	ATRC2\|CAT2\|HCAT2
	Cytomap	1p36.22	8p22
	Type of gene	protein-coding	protein-coding
	Description	calsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha	cationic amino acid transporter 2low affinity cationic amino acid transporter 2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
	Modification date	20180523	20180523
	UniProtAcc	O94985	P52569
	Ensembl transtripts involved in fusion gene	ENST00000377298, ENST00000361311, ENST00000377288, ENST00000477264,	ENST00000494857, ENST00000522656, ENST00000470360, ENST00000004531, ENST00000398090,
Fusion gene scores	* DoF score	11 X 10 X 5=550	2 X 2 X 1=4
	# samples	15	2
	** MAII score	log2(15/550*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: CLSTN1 [Title/Abstract] AND SLC7A2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BP395070	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000377298	ENST00000494857	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-intron	ENST00000377298	ENST00000522656	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377298	ENST00000470360	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377298	ENST00000004531	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377298	ENST00000398090	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000361311	ENST00000494857	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-intron	ENST00000361311	ENST00000522656	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000361311	ENST00000470360	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000361311	ENST00000004531	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000361311	ENST00000398090	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377288	ENST00000494857	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-intron	ENST00000377288	ENST00000522656	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377288	ENST00000470360	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377288	ENST00000004531	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000377288	ENST00000398090	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000477264	ENST00000494857	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-intron	ENST00000477264	ENST00000522656	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000477264	ENST00000470360	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000477264	ENST00000004531	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+
intron-3UTR	ENST00000477264	ENST00000398090	CLSTN1	chr1	9789921	+	SLC7A2	chr8	17427501	+

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FusionProtFeatures for CLSTN1_SLC7A2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLSTN1 O94985	SLC7A2 P52569

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Fusion gene ID: 7506

FusionGeneSummary for CLSTN1_SLC7A2

FusionProtFeatures for CLSTN1_SLC7A2