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Fusion gene ID: 7496 |
FusionGeneSummary for CLSPN_CANX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLSPN_CANX | Fusion gene ID: 7496 | Hgene | Tgene | Gene symbol | CLSPN | CANX | Gene ID | 63967 | 821 |
| Gene name | claspin | calnexin | |
| Synonyms | - | CNX|IP90|P90 | |
| Cytomap | 1p34.3 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | claspinclaspin homolog | calnexinmajor histocompatibility complex class I antigen-binding protein p88 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q9HAW4 | P27824 | |
| Ensembl transtripts involved in fusion gene | ENST00000251195, ENST00000466308, ENST00000373220, ENST00000520551, ENST00000318121, | ENST00000504734, ENST00000415618, ENST00000452673, ENST00000247461, ENST00000512607, ENST00000503126, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 12 X 1=108 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/108*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLSPN [Title/Abstract] AND CANX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLSPN | GO:0007095 | mitotic G2 DNA damage checkpoint | 18662541 |
| Hgene | CLSPN | GO:0018105 | peptidyl-serine phosphorylation | 16885022 |
| Hgene | CLSPN | GO:0032147 | activation of protein kinase activity | 16885022 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI019346 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000251195 | ENST00000504734 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000251195 | ENST00000415618 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000251195 | ENST00000452673 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000251195 | ENST00000247461 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000251195 | ENST00000512607 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-intron | ENST00000251195 | ENST00000503126 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000466308 | ENST00000504734 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000466308 | ENST00000415618 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000466308 | ENST00000452673 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000466308 | ENST00000247461 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000466308 | ENST00000512607 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-intron | ENST00000466308 | ENST00000503126 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000373220 | ENST00000504734 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000373220 | ENST00000415618 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000373220 | ENST00000452673 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000373220 | ENST00000247461 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000373220 | ENST00000512607 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-intron | ENST00000373220 | ENST00000503126 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000520551 | ENST00000504734 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000520551 | ENST00000415618 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000520551 | ENST00000452673 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000520551 | ENST00000247461 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000520551 | ENST00000512607 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-intron | ENST00000520551 | ENST00000503126 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000318121 | ENST00000504734 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000318121 | ENST00000415618 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000318121 | ENST00000452673 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000318121 | ENST00000247461 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-3CDS | ENST00000318121 | ENST00000512607 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
| intron-intron | ENST00000318121 | ENST00000503126 | CLSPN | chr1 | 36230155 | - | CANX | chr5 | 179136910 | - |
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FusionProtFeatures for CLSPN_CANX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLSPN | CANX |