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Fusion gene ID: 7478 |
FusionGeneSummary for CLPTM1L_SCUBE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLPTM1L_SCUBE1 | Fusion gene ID: 7478 | Hgene | Tgene | Gene symbol | CLPTM1L | SCUBE1 | Gene ID | 81037 | 80274 |
| Gene name | CLPTM1 like | signal peptide, CUB domain and EGF like domain containing 1 | |
| Synonyms | CRR9 | - | |
| Cytomap | 5p15.33 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cleft lip and palate transmembrane protein 1-like proteinCLPTM1-like proteincisplatin resistance related protein CRR9pcisplatin resistance-related protein 9 | signal peptide, CUB and EGF-like domain-containing protein 1signal peptide, CUB domain, EGF-like 1signal peptide-CUB domain-EGF-related 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96KA5 | Q8IWY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000320895, ENST00000507807, ENST00000320927, ENST00000506641, | ENST00000360835, ENST00000290460, ENST00000470433, | |
| Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 7 X 6 X 7=294 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLPTM1L [Title/Abstract] AND SCUBE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRP | TCGA-P4-A5EB-01A | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000320895 | ENST00000360835 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000320895 | ENST00000290460 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000320895 | ENST00000470433 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000507807 | ENST00000360835 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000507807 | ENST00000290460 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000507807 | ENST00000470433 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000320927 | ENST00000360835 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000320927 | ENST00000290460 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5CDS-intron | ENST00000320927 | ENST00000470433 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5UTR-intron | ENST00000506641 | ENST00000360835 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5UTR-intron | ENST00000506641 | ENST00000290460 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
| 5UTR-intron | ENST00000506641 | ENST00000470433 | CLPTM1L | chr5 | 1322992 | - | SCUBE1 | chr22 | 43651583 | - |
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FusionProtFeatures for CLPTM1L_SCUBE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLPTM1L | SCUBE1 |