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Fusion gene ID: 7457

FusionGeneSummary for CLOCK_SRD5A3

Fusion gene summary

Fusion gene information	Fusion gene name: CLOCK_SRD5A3
	Fusion gene ID: 7457
		Hgene	Tgene
	Gene symbol	CLOCK	SRD5A3
	Gene ID	9575	79644
	Gene name	clock circadian regulator	steroid 5 alpha-reductase 3
	Synonyms	KAT13D\|bHLHe8	CDG1P\|CDG1Q\|KRIZI\|SRD5A2L\|SRD5A2L1
	Cytomap	4q12	4q12
	Type of gene	protein-coding	protein-coding
	Description	circadian locomoter output cycles protein kaputcircadian locomoter output cycles kaput proteinclass E basic helix-loop-helix protein 8clock homolog	polyprenol reductase3-oxo-5-alpha-steroid 4-dehydrogenase 3S5AR 3SR type 3probable polyprenol reductase
	Modification date	20180519	20180523
	UniProtAcc	O15516	Q9H8P0
	Ensembl transtripts involved in fusion gene	ENST00000309964, ENST00000381322, ENST00000513440, ENST00000506923,	ENST00000264228, ENST00000514398,
Fusion gene scores	* DoF score	6 X 8 X 5=240	3 X 2 X 3=18
	# samples	8	3
	** MAII score	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CLOCK [Title/Abstract] AND SRD5A3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLOCK	GO:0006473	protein acetylation	28985504
Hgene	CLOCK	GO:0032922	circadian regulation of gene expression	24005054
Hgene	CLOCK	GO:0045893	positive regulation of transcription, DNA-templated	23785138
Hgene	CLOCK	GO:0051775	response to redox state	11441146
Hgene	CLOCK	GO:0071479	cellular response to ionizing radiation	21659603
Tgene	SRD5A3	GO:0016095	polyprenol catabolic process	20637498
Tgene	SRD5A3	GO:0019348	dolichol metabolic process	20637498

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-22-5478-01A	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000309964	ENST00000264228	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
5CDS-3UTR	ENST00000309964	ENST00000514398	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
Frame-shift	ENST00000381322	ENST00000264228	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
5CDS-3UTR	ENST00000381322	ENST00000514398	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
Frame-shift	ENST00000513440	ENST00000264228	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
5CDS-3UTR	ENST00000513440	ENST00000514398	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
intron-3CDS	ENST00000506923	ENST00000264228	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+
intron-3UTR	ENST00000506923	ENST00000514398	CLOCK	chr4	56308599	-	SRD5A3	chr4	56225513	+

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FusionProtFeatures for CLOCK_SRD5A3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLOCK O15516	SRD5A3 Q9H8P0

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Fusion gene ID: 7457

FusionGeneSummary for CLOCK_SRD5A3

FusionProtFeatures for CLOCK_SRD5A3