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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7456

FusionGeneSummary for CLOCK_PHF21A

check button Fusion gene summary
Fusion gene informationFusion gene name: CLOCK_PHF21A
Fusion gene ID: 7456
HgeneTgene
Gene symbol

CLOCK

PHF21A

Gene ID

9575

51317

Gene nameclock circadian regulatorPHD finger protein 21A
SynonymsKAT13D|bHLHe8BHC80|BM-006
Cytomap

4q12

11p11.2

Type of geneprotein-codingprotein-coding
Descriptioncircadian locomoter output cycles protein kaputcircadian locomoter output cycles kaput proteinclass E basic helix-loop-helix protein 8clock homologPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)
Modification date2018051920180523
UniProtAcc

O15516

Q96BD5

Ensembl transtripts involved in fusion geneENST00000309964, ENST00000381322, 
ENST00000513440, ENST00000506923, 
ENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
Fusion gene scores* DoF score6 X 8 X 5=2407 X 7 X 4=196
# samples 89
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLOCK [Title/Abstract] AND PHF21A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLOCK

GO:0006473

protein acetylation

28985504

HgeneCLOCK

GO:0032922

circadian regulation of gene expression

24005054

HgeneCLOCK

GO:0045893

positive regulation of transcription, DNA-templated

23785138

HgeneCLOCK

GO:0051775

response to redox state

11441146

HgeneCLOCK

GO:0071479

cellular response to ionizing radiation

21659603


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-38-4631-01ACLOCKchr4

56319221

-PHF21Achr11

46001517

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309964ENST00000257821CLOCKchr4

56319221

-PHF21Achr11

46001517

-
In-frameENST00000309964ENST00000323180CLOCKchr4

56319221

-PHF21Achr11

46001517

-
In-frameENST00000309964ENST00000418153CLOCKchr4

56319221

-PHF21Achr11

46001517

-
5CDS-intronENST00000309964ENST00000527753CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000381322ENST00000257821CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000381322ENST00000323180CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000381322ENST00000418153CLOCKchr4

56319221

-PHF21Achr11

46001517

-
5CDS-intronENST00000381322ENST00000527753CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000513440ENST00000257821CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000513440ENST00000323180CLOCKchr4

56319221

-PHF21Achr11

46001517

-
Frame-shiftENST00000513440ENST00000418153CLOCKchr4

56319221

-PHF21Achr11

46001517

-
5CDS-intronENST00000513440ENST00000527753CLOCKchr4

56319221

-PHF21Achr11

46001517

-
intron-3CDSENST00000506923ENST00000257821CLOCKchr4

56319221

-PHF21Achr11

46001517

-
intron-3CDSENST00000506923ENST00000323180CLOCKchr4

56319221

-PHF21Achr11

46001517

-
intron-3CDSENST00000506923ENST00000418153CLOCKchr4

56319221

-PHF21Achr11

46001517

-
intron-intronENST00000506923ENST00000527753CLOCKchr4

56319221

-PHF21Achr11

46001517

-

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FusionProtFeatures for CLOCK_PHF21A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLOCK

O15516

PHF21A

Q96BD5

Transcriptional activator which forms a core componentof the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes throughthe generation of approximately 24 hour circadian rhythms in geneexpression, which are translated into rhythms in metabolism andbehavior. It is derived from the Latin roots 'circa' (about) and'diem' (day) and acts as an important regulator of a wide array ofphysiological functions including metabolism, sleep, bodytemperature, blood pressure, endocrine, immune, cardiovascular,and renal function. Consists of two major components: the centralclock, residing in the suprachiasmatic nucleus (SCN) of the brain,and the peripheral clocks that are present in nearly every tissueand organ system. Both the central and peripheral clocks can bereset by environmental cues, also known as Zeitgebers (German for'timegivers'). The predominant Zeitgeber for the central clock islight, which is sensed by retina and signals directly to the SCN.The central clock entrains the peripheral clocks through neuronaland hormonal signals, body temperature and feeding-related cues,aligning all clocks with the external light/dark cycle. Circadianrhythms allow an organism to achieve temporal homeostasis with itsenvironment at the molecular level by regulating gene expressionto create a peak of protein expression once every 24 hours tocontrol when a particular physiological process is most activewith respect to the solar day. Transcription and translation ofcore clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2,PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythmgeneration, whereas delays imposed by post-translationalmodifications (PTMs) are important for determining the period(tau) of the rhythms (tau refers to the period of a rhythm and isthe length, in time, of one complete cycle). A diurnal rhythm issynchronized with the day/night cycle, while the ultradian andinfradian rhythms have a period shorter and longer than 24 hours,respectively. Disruptions in the circadian rhythms contribute tothe pathology of cardiovascular diseases, cancer, metabolicsyndromes and aging. A transcription/translation feedback loop(TTFL) forms the core of the molecular circadian clock mechanism.Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 orARNTL2/BMAL2, form the positive limb of the feedback loop, act inthe form of a heterodimer and activate the transcription of coreclock genes and clock-controlled genes (involved in key metabolicprocesses), harboring E-box elements (5'-CACGTG-3') within theirpromoters. The core clock genes: PER1/2/3 and CRY1/2 which aretranscriptional repressors form the negative limb of the feedbackloop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2heterodimer inhibiting its activity and thereby negativelyregulating their own expression. This heterodimer also activatesnuclear receptors NR1D1/2 and RORA/B/G, which form a secondfeedback loop and which activate and repress ARNTL/BMAL1transcription, respectively. Regulates the circadian expression ofICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer ofthe transactivation potential of NF-kappaB. Plays an importantrole in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1heterodimer regulates the circadian expression of SERPINE1/PAI1,VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1,GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and alsogenes implicated in glucose and lipid metabolism. Promotesrhythmic chromatin opening, regulating the DNA accessibility ofother transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimeractivates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. Thepreferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is5'-CACGTGA-3', which contains a flanking Ala residue in additionto the canonical 6-nucleotide E-box sequence (PubMed:23229515).CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTLbinds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-boxmotifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCKhas an intrinsic acetyltransferase activity, which enablescircadian chromatin remodeling by acetylating histones andnonhistone proteins, including its own partner ARNTL/BMAL1.Represses glucocorticoid receptor NR3C1/GR-induced transcriptionalactivity by reducing the association of NR3C1/GR to glucocorticoidresponse elements (GREs) via the acetylation of multiple lysineresidues located in its hinge region (PubMed:21980503). Theacetyltransferase activity of CLOCK is as important as itstranscription activity in circadian control. Acetylates metabolicenzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated byBMAL1, rhythmically interacts and acetylates argininosuccinatesynthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as wellas the circadian oscillation of arginine biosynthesis andsubsequent ureagenesis (PubMed:28985504).{ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630,ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503,ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515,ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054,ECO:0000269|PubMed:28985504}. Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422107_177402847DomainPAS 1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422262_332402847DomainPAS 2
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422336_379402847DomainNote=PAC
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-142234_84402847DomainbHLH
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624107_177402847DomainPAS 1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624262_332402847DomainPAS 2
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624336_379402847DomainNote=PAC
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-162434_84402847DomainbHLH
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523107_177402847DomainPAS 1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523262_332402847DomainPAS 2
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523336_379402847DomainNote=PAC
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-152334_84402847DomainbHLH
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-142232_47402847MotifNuclear localization signal
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-162432_47402847MotifNuclear localization signal
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-152332_47402847MotifNuclear localization signal
TgenePHF21Achr4:56319221chr11:46001517ENST00000257821-418558_60351682Coiled coilOntology_term=ECO:0000255
TgenePHF21Achr4:56319221chr11:46001517ENST00000323180-418558_60351635Coiled coilOntology_term=ECO:0000255
TgenePHF21Achr4:56319221chr11:46001517ENST00000418153-418558_60351681Coiled coilOntology_term=ECO:0000255
TgenePHF21Achr4:56319221chr11:46001517ENST00000257821-418425_43751682DNA bindingNote=A.T hook
TgenePHF21Achr4:56319221chr11:46001517ENST00000323180-418425_43751635DNA bindingNote=A.T hook
TgenePHF21Achr4:56319221chr11:46001517ENST00000418153-418425_43751681DNA bindingNote=A.T hook
TgenePHF21Achr4:56319221chr11:46001517ENST00000257821-418486_68051682RegionNote=Required for transcriptional repression
TgenePHF21Achr4:56319221chr11:46001517ENST00000323180-418486_68051635RegionNote=Required for transcriptional repression
TgenePHF21Achr4:56319221chr11:46001517ENST00000418153-418486_68051681RegionNote=Required for transcriptional repression
TgenePHF21Achr4:56319221chr11:46001517ENST00000257821-418488_53551682Zinc fingerPHD-type
TgenePHF21Achr4:56319221chr11:46001517ENST00000323180-418488_53551635Zinc fingerPHD-type
TgenePHF21Achr4:56319221chr11:46001517ENST00000418153-418488_53551681Zinc fingerPHD-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422744_760402847Compositional biasNote=Gln-rich
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422819_828402847Compositional biasNote=Poly-Gln
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624744_760402847Compositional biasNote=Gln-rich
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624819_828402847Compositional biasNote=Poly-Gln
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523744_760402847Compositional biasNote=Gln-rich
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523819_828402847Compositional biasNote=Poly-Gln
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422514_564402847RegionImplicated in the circadian rhythmicity
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624514_564402847RegionImplicated in the circadian rhythmicity
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523514_564402847RegionImplicated in the circadian rhythmicity
TgenePHF21Achr4:56319221chr11:46001517ENST00000257821-4184_10851682Compositional biasNote=Gln-rich
TgenePHF21Achr4:56319221chr11:46001517ENST00000323180-4184_10851635Compositional biasNote=Gln-rich
TgenePHF21Achr4:56319221chr11:46001517ENST00000418153-4184_10851681Compositional biasNote=Gln-rich


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FusionGeneSequence for CLOCK_PHF21A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000257821_chr11_46001517_-_1033aa
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQ
NSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAF
MVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPEN
EKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGT
LAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEA

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000323180_chr11_46001517_-_986aa
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQ
NSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAF
MVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRANEEHWPKGDIHEDFCSVCRKSGQLLMCDT
CSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSIS

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000418153_chr11_46001517_-_1032aa
MLFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAQ
SDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSL
TPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYH
QWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETAADKKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQ
QYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGP
GAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQN
SIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAFM
VSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENE
KTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTL
AIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEAT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000257821_chr11_46001517_-_3099nt
ATGTTGTTTACCGTAAGCTGTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGAC
AAGGACAAAGCGAAAAGAGTATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATG
CTTCCTGGTAATGCTAGAAAGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAG
TCAGATGCTAGTGAAATTCGACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGT
TTTTTTTTAGCAATCATGACAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTG
GATCAAAGTATATTTAATTTTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTA
ACCCCAGAATATTTAAAATCAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTAT
GAATATGTAAAATTTATAGGAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACA
CATAGGCCATCTTATGAAGATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAA
GAACCCAATGAAGAGTTTACATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTG
CCATTTGAAGTTCTGGGAACATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAA
TATGGGAAAGGCAAATCATGTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCAT
CAGTGGAATTCAAGGCCAGAGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGC
ATTGAAGAGTCTCTTCCTGAGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCG
GACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAG
CAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATT
ACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTG
ACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCT
GGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTT
ATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCA
GCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAG
AATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATA
GCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAA
ACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTC
ATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCG
GTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGA
GGTCGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAAT
GAAAAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAG
GATTTTTGCAGCGTTTGCAGAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCT
CTGAAAACAATTCCCAAGGGCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACT
TTAGCAATTGTTCATTCCTATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAA
GAACGAGAACAACTAGAGCAAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAG
AAGGAGATGCACAGCTCCCTGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCC
ACTGTGGGGGCCATCTCCAATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGC

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000323180_chr11_46001517_-_2958nt
ATGTTGTTTACCGTAAGCTGTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGAC
AAGGACAAAGCGAAAAGAGTATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATG
CTTCCTGGTAATGCTAGAAAGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAG
TCAGATGCTAGTGAAATTCGACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGT
TTTTTTTTAGCAATCATGACAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTG
GATCAAAGTATATTTAATTTTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTA
ACCCCAGAATATTTAAAATCAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTAT
GAATATGTAAAATTTATAGGAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACA
CATAGGCCATCTTATGAAGATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAA
GAACCCAATGAAGAGTTTACATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTG
CCATTTGAAGTTCTGGGAACATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAA
TATGGGAAAGGCAAATCATGTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCAT
CAGTGGAATTCAAGGCCAGAGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGC
ATTGAAGAGTCTCTTCCTGAGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCG
GACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAG
CAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATT
ACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTG
ACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCT
GGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTT
ATCCCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCA
GCACCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAG
AATTCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATA
GCTACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAA
ACAGATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTC
ATGGTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCG
GTCTACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGA
GCCAATGAGGAACACTGGCCAAAGGGTGATATTCATGAGGATTTTTGCAGCGTTTGCAGAAAAAGTGGCCAGTTACTGATGTGCGACACA
TGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGGGCATGTGGATCTGTCCCAGATGTCAGGACCAG
ATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCTATATTGCCTACAAAGCAGCAAAAGAAGAAGAG
AAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGCAAAAGGTGAAACAGCTCAGCAATTCCATAAGT
AAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCCTGGAGAAGGTAAAACAGCTGATTCGCCTCATC
CACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCAATGGCCCGGACTGCACCCCCCCTGCCAATGCC

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000418153_chr11_46001517_-_3096nt
ATGTTGTTTACCGTAAGCTGTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGAC
AAGGACAAAGCGAAAAGAGTATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATG
CTTCCTGGTAATGCTAGAAAGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAG
TCAGATGCTAGTGAAATTCGACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGT
TTTTTTTTAGCAATCATGACAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTG
GATCAAAGTATATTTAATTTTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTA
ACCCCAGAATATTTAAAATCAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTAT
GAATATGTAAAATTTATAGGAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACA
CATAGGCCATCTTATGAAGATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAA
GAACCCAATGAAGAGTTTACATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTG
CCATTTGAAGTTCTGGGAACATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAA
TATGGGAAAGGCAAATCATGTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCAT
CAGTGGAATTCAAGGCCAGAGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGC
ATTGAAGAGTCTCTTCCTGAGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCG
GACAAGTTCCAAATACAGCCATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAG
CAGTACCACCACCACCACGCCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATT
ACCACAAAGACACTACCTCTCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTG
ACCGCCATCAACAGTCAGAAGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCT
GGGGCAGAGGCTGTCCAAATTGTGGCAAAAAACACAGTCACTCTGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATC
CCCCCTCCTAGACTCACTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCA
CCACCTCCCATGCTCGCAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAAT
TCCATCCACCCCGTCCGTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCT
ACTCCAGGGACCAGACTCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACA
GATGAGAAACAAACAGAGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATG
GTGTCTCTAGGGTTGGTAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTC
TACAGTGGAGCAGTCTTTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGT
CGTCCTCCAAAATACAATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAA
AAGACAGAGACCACATTCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAGGAT
TTTTGCAGCGTTTGCAGAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTG
AAAACAATTCCCAAGGGCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTA
GCAATTGTTCATTCCTATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAA
CGAGAACAACTAGAGCAAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAG
GAGATGCACAGCTCCCTGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACT
GTGGGGGCCATCTCCAATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGCTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000257821_chr11_46001517_-_7998nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCA
CTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCG
CAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCC
GTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGAC
TCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAG
AGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGG
TAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCT
TTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACA
ATGCAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACAT
TCACTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAGGATTTTTGCAGCGTTTGCA
GAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGG
GCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCT
ATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGC
AAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCC
TGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCA
ATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACC
AGGGGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCCCGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAA
GCAAAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCAGAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTT
TGCCAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGTTACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCAC
CATGCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTGCCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTG
TTTTCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAGATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGAC
AAGTCCAAAGAGTGTGTGGGCTTTCCTGTTTCTAAACTTTCGCTACTATAAAACCAAAAAAAGGAATTGAGATTTCACCAACCCCAGTGC
CCAGAAGAGGGAAGGGGAGTGGCTGGAGGGAGCAGGGGGTGGGACAGTGTATCAAATAAGCAGTATTTAATCACCTCTGGCGGGGGCCTC
GTGCAAGGGGAGACTGACACCAAGAACAGCCAGTAGGTTCTTCTCCCCTGCACTCTGCTCCCTGCGCGGTAACCCCACCACTCCTGAAGC
CTGCCCAGTCTCCTTCCTTCCCTGCTTGGTGAGTCGCGCATCTCCGTGGTTATCCCGCTGTCTCCTCTCCAAGAACAAGCAGAGCCCGGG
CCACTGGCCCTTGCCCAAGGCAGGGAAGAAGGATGTGTGTGTCCAGGAAGGAAAAAAAGGTGGATCAGTGATTTTACTTGAAAACAAGCT
CCATCCCTTTTCTATATTTATAAGAAGAGAAGATCTTGAGTGAAGCAGCACGCGACCCAGGTGTGTGTGAATTGAATGGAGACGTTTCTT
TTCTCTTTCTTTAATTTTTGTTTTTGTTCTTTTTTTCTTTAAGGAAAGTTTTATTTTACTGTTCATTTTACTTTCTTGGTAACAAAAACT
AAAATAAGGAATAGAAAAGCTGTTTTTCAGGCTGACAGTCCAATTAAGGGTAGCCAAGACCTTGCATGGTAGAGTAGGAATCATAGTGTC
AGTGAGGTCCCGTGAGTCTTTGTGAGTCCTTGTGTCATCGTTCGGGCACTGTTTTTTTATGCAAGGGCAAAAATCTTTGTATCTGGGGAA
AAAAAACTTTTTTTTAAATTAAAAAGGAAAATAAAAGATATTGAGGTCTTCCTAGTGTTACTTAAATTAAGATCAAGGTAAGAAACATTG
TAAAAAAAAATTACAAAAGTGCTATTTGTTTCCTAAAAACAGTGATTTCTATTAAAAAGGTGTCAGAACTGGAGAAAATGCCGTGTAGTT
ATAATTTTTTAGCACAGACCCTGCTGATCACGATGACATTTTGCCGTGTGTGTGTCTCTAGACTGGTGGGCCAGTCTCCTTGAAGGACAG
AGGCGGAGCTCCCCACCCTTCTCTCTCCTCAGAAAAGACCGTGCTCTCTTCTTGGTGCAGGGATCTTGTCTCCTGTTGTGAAGCCCAAAT
GGAAGCGTGGATGGTATCAGGGCCCTACCCGTGGTCTTCTCAGATTCTGCTAGAGCAAAAGGCTGGTGCCTAAATAAGATCCCTTCCTTT
GGTGCTGCTTTTGGTCTTTCAGCCACCAGCATTATGAGTGCCTGGGGGACACCTCCGAGGGAACTGGCCAGCGGAGCTCTGTGGTGCGCA
CGCACCCTGGCCGTGACAGGAGGGTGCGGGAGTACAGGCTGGCTGCATCAGCCCTTGGTGCTTAGAACAGAGGAGGAGTGACATGTTTTG
AGGGTACGTCTCTGAGACAGAGCCCCAGCGTGGCCTTCGCTCTGTCTTGCCTTTGGGGAGAGGTCTGAAGCTCCCACTCCTTTCTCTGCC
TGTTGGCTCCAGGCACCAGAAATTTACTCCACTCCACCCACCCACAAGCCTCCTGGGTGACCCTGGGCTAGAATTGCTGCGCTTGCCTCG
GCTTGGCCGGTTGTGGCCTCTCCTTGAGAAAACCAGGGTTGTGAAAGACTCAGACCATTCTCTCATCTTGCCTTGTCAGAAGTAAATTGT
GTCAGATTTGTGCTCTCGCTGGAGACCTTTGCCCCTTGCGTGCCCCTGGCCGATGGGAGGGCGGTGGAGGCTCTGTACCCTGGCCCTGCT
GGAGCATCTCCCCCAAGCCCACTCCAGGCCCTGGGAATGGCCAGAGTCTAGGAGAGGTAGAAACGATCCTATCAGCTTCTCTCCCACCCA
ATTAGGCCCAGAGAGACAAAGACAGATCTGAAAGCAAATGCAACAGAGAAGAGACACTTCTTAGAGTAAAATGTGTCTCATCTCTATCAG
CCATCGCCTTTCATCTTCCCAGGGGCCTCAGAAGAAGGAATTAAGTTAGGCTGAACAGGCCTCAGAGTTAGGCCCTGGCTGCTTGATTGG
CTGAGGGGGAAAGAGTTCCCTTTTCTCATTCAGAAACCAAGGTGCTGTGTCTAGTCAGGGAGCCTTGGAGATGCCTGGACTAGTTGGAGG
AATCGTTGGCAGAGGATCAGAGACCAGCAGCAGGCTGTCTGCCCTGTCTAGAGCTCTTCCCCTCAACTTGTCTGGGCCCATCTGGGGGTT
GCCACACAACACCTAACTTACCTTTTCCTGAAAGAAGTTGGGAAACCATCATCACTAGAGGCCTTTGCTCAGAGAGGAGCTGCCTTAGGA
GTCTTGGGTCGGAGGACGGGGCTAGGAATTGACCAGGGCTTTGCCTGCCGCCCTCAGCAGTGTCGGGTACATTCTGACCTCGCCTGCAGC
TGGGCTGTGGATTCTTCCTGACATTCAGATGTGAGCTGTTTTGGGAGTCAGCTAGTATGGAGTACGAGATGCAACCCAGCCCCCAAACCT
ACATTCTGCACTCAAATTCCAAAACACTGCTTTACTGTAAAGAAGAGGCCCCTGGCACCCAATCTCCCTGTCCTTCACTGTCCCCTCAGA
CCTGGGCGGGGAGGGGGGGGGGCCTGTGACCACCTGAGACATACGCTCGTGACACTGCCCCACCCCAGCCACCTCCACTTGCTTCCTCCT
CCTTCCCTCCGCTGCTCTTTCCCCACGGCCCAGAATTTAGCTGCTCTGACAGCCACTTTTGAGACCAGCTGGCTTTGTAGTCACTTCAGA
GAGCTGGAGCGGCTGCCCACTGGGCCCTGACTGGGAGTCCCCTGCCAGCTCCTGATCAGGCGCTGCGCCCTGGTGGCAGTGATGACTGGG
AGTCCCCTGCCAGCTCCTGTCCAGGCGCTGCATCCTGGTAACAGTGAGGCCATGTTGCTGTCATCTCCACCTCTGCATTCTTGCTGCCTG
TGGGTCCTTTTTCTTTCATGGAGCCTGCTGGGTCTTGTCTCACCTGTGCTGAGCTCCTCTGGGGTTTTGATTTCTTCCTTCCTTATCAGG
CCCTTTGGGGTAAGCCTGCTGGTTGTACCTGACATAGGGAGGCAGTTAGGGGCAGTCCCTGGTGGGGCCGCCCTGGCAGCCTCCAGCTGG
CACCATCGTGTGCCTGGTTTCCCTGCAACACCTGCCTCTCTGTCCCTGCTGCTGCTTGGCTCAGGCCCAACAGGCAGCGTGCATGGAGGT
GGTTACACACAGCTGTTTCCGTGAGGGTGACCGTGTCTGCAGCACGCTTCCGTCTCCGCATGCACGGCTGCCTCTCCAGCCACCTCTGAT
ACTTCTCTCTTGGGGCCATCAGAGCCTCCCTTGGGCTGTCACCTCCCAGCTCACACACACTCTTCAGTGGTTTCCTCTCTTCATTCTCTT
ATAGGGCGTGGTCCTTCTTATTTATCTAAAGGGCTGAATTTAGGAGACTTTTTACCCAGGGGCAAAAGGCTCTTAGGGTAATGAGATGGA
TGGTGGCCCAGGTGCATTTTCCAGGGCCTGGGTTCTCCAGATCCCGTGGCTTCTGTTGAGTGGAGGCAACTTTGCTCTGTGTGAACCTCG
CCCCTGTCCCTCTGCCGGGCACCCCTGGCAGGAAGCAGGACTCCCATCCTCACCCTGACTTAGACTGTCCTCTGAGTCAGCTCCTCTCCA
AGACAGGAGTGGGCAGCCCTGGGCAGTCTTCTGGCCCCTTGCTAAAGTGAGGGGCAGGAAGCTGGGGCTGCCCTCCAGAAAGCCGGGGTA
GGAACTCTGAAAAATACCTCCTCTAAACGGAAGCAGGGCTCTCCAGTTCCACTTGGCGCCCCCTCCCACAAGGCCCTTCCTCCCTGAGGA
CCCCACCCCCCTACCCCTTCCCCAGCAGCCTTTGGACCCTCACCTCTCTCCGGTGTCCGTGGGTCCTCAGCCCAGGGTGAGCTGCAGTCA
GGCGGGATGGGACGGGCAGGCCAGAGGTCAGCCAGCTCCTAGCAGAGAAGAGCCAGCCAGACCCCAACCCTGTCTCTTGTCCATGCCCTT
TGTGATTTCAGTCTTGGTAGACTTGTATTTGGAGTTTTGTGCTTCAAAGTTTTTGTTTTTGTTTGTTTGGTTTTTGTTTTGAGGGGGTGG

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000323180_chr11_46001517_-_4611nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGCAGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCA
CTCCACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCG
CAGCTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCC
GTGTCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGAC
TCGCTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAG
AGAGCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGG
TAACACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCT
TTGAGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGCCAATGAGGAACACTGGC
CAAAGGGTGATATTCATGAGGATTTTTGCAGCGTTTGCAGAAAAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATT
TGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGGGCATGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAG
CAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCTATATTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAAT
GGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGCAAAAGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGA
ACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCCTGGAGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCA
AACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCAATGGCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCC
CTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACCAGGGGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCC
CGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAAGCAAAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCA
GAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTTTGCCAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGT
TACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCACCATGCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTG
CCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTGTTTTCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAG
ATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGACAAGTCCAAAGAGTGTGTGGGCTTTCCTGTTTCTAAACTTTCGCTACTATAA
AACCAAAAAAAGGAATTGAGATTTCACCAACCCCAGTGCCCAGAAGAGGGAAGGGGAGTGGCTGGAGGGAGCAGGGGGTGGGACAGTGTA
TCAAATAAGCAGTATTTAATCACCTCTGGCGGGGGCCTCGTGCAAGGGGAGACTGACACCAAGAACAGCCAGTAGGTTCTTCTCCCCTGC
ACTCTGCTCCCTGCGCGGTAACCCCACCACTCCTGAAGCCTGCCCAGTCTCCTTCCTTCCCTGCTTGGTGAGTCGCGCATCTCCGTGGTT
ATCCCGCTGTCTCCTCTCCAAGAACAAGCAGAGCCCGGGCCACTGGCCCTTGCCCAAGGCAGGGAAGAAGGATGTGTGTGTCCAGGAAGG
AAAAAAAGGTGGATCAGTGATTTTACTTGAAAACAAGCTCCATCCCTTTTCTATATTTATAAGAAGAGAAGATCTTGAGTGAAGCAGCAC
GCGACCCAGGTGTGTGTGAATTGAATGGAGACGTTTCTTTTCTCTTTCTTTAATTTTTGTTTTTGTTCTTTTTTTCTTTAAGGAAAGTTT
TATTTTACTGTTCATTTTACTTTCTTGGTAACAAAAACTAAAATAAGGAATAGAAAAGCTGTTTTTCAGGCTGACAGTCCAATTAAGGGT
AGCCAAGACCTTGCATGGTAGAGTAGGAATCATAGTGTCAGTGAGGTCCCGTGAGTCTTTGTGAGTCCTTGTGTCATCGTTCGGGCACTG
TTTTTTTATGCAAGGGCAAAAATCTTTGTATCTGGGGAAAAAAAACTTTTTTTTAAATTAAAAAGGAAAATAAAAGATATTGAGGTCTTC
CTAGTGTTACTTAAATTAAGATCAAGGTAAGAAACATTGTAAAAAAAAATTACAAAAGTGCTATTTGTTTCCTAAAAACAGTGATTTCTA

>In-frame_CLOCK_ENST00000309964_chr4_56319221_-_PHF21A_ENST00000418153_chr11_46001517_-_3834nt
AGCTGATTCTATCACATTGTAAGATGCCTTTGGATAATTCTACAGTCCTCTTAAATGAATCTTTAGAACTTGGCAAGTCTCACTAGATAC
CTTCAATCATCATTTTGAGCTCAAAGAATTCTGAGACTTATGGTTGGTCATATAGAAGAGTACCTTGAACCTATAGTTTCCTGAAGAATC
AGTTTAAAAGATCCAAGGAGTACAAAAGGAGAAGTACAAATGTCTACTACAAGACGAAAACGTAGTATGTTATGTTGTTTACCGTAAGCT
GTAGTAAAATGAGCTCGATTGTTGACAGAGATGACAGTAGTATTTTTGATGGGTTGGTGGAAGAAGATGACAAGGACAAAGCGAAAAGAG
TATCTAGAAACAAATCTGAAAAGAAACGTAGAGATCAATTTAATGTTCTCATTAAAGAACTGGGATCCATGCTTCCTGGTAATGCTAGAA
AGATGGACAAATCTACTGTTCTGCAGAAAAGCATTGATTTTTTACGAAAACATAAAGAAATCACTGCACAGTCAGATGCTAGTGAAATTC
GACAGGACTGGAAACCTACATTCCTTAGTAATGAAGAGTTTACACAATTAATGTTAGAGGCTCTTGATGGTTTTTTTTTAGCAATCATGA
CAGATGGAAGCATAATATATGTGTCTGAGAGTGTAACTTCATTACTTGAACATTTACCATCTGATCTTGTGGATCAAAGTATATTTAATT
TTATCCCAGAAGGGGAACATTCAGAGGTTTATAAAATACTCTCTACTCATCTGCTGGAAAGTGATTCATTAACCCCAGAATATTTAAAAT
CAAAAAATCAGTTAGAATTCTGTTGTCACATGCTGCGAGGAACAATAGACCCAAAGGAGCCATCTACCTATGAATATGTAAAATTTATAG
GAAATTTCAAATCTTTAAACAGTGTATCCTCTTCAGCACACAATGGTTTTGAAGGAACTATACAACGCACACATAGGCCATCTTATGAAG
ATAGAGTTTGTTTTGTAGCTACTGTCAGGTTAGCTACACCTCAGTTCATCAAGGAAATGTGCACTGTTGAAGAACCCAATGAAGAGTTTA
CATCTAGACATAGTTTAGAATGGAAGTTTCTGTTTCTAGATCACAGGGCACCACCCATAATAGGGTATTTGCCATTTGAAGTTCTGGGAA
CATCAGGCTATGATTACTATCATGTGGATGACCTAGAAAATTTGGCAAAATGTCATGAGCACTTAATGCAATATGGGAAAGGCAAATCAT
GTTATTATAGGTTCCTGACTAAGGGGCAACAGTGGATTTGGCTTCAGACTCATTATTATATCACTTACCATCAGTGGAATTCAAGGCCAG
AGTTTATTGTTTGTACTCACACTGTAGTAAGTTATGCAGAAGTTAGGGCTGAAAGACGACGAGAACTTGGCATTGAAGAGTCTCTTCCTG
AGACAGCTGCTGACAAAAAAAGAGTAGTTGAACAGCTACGGAAGAACCTGATAGTAAAGCAAGAACAACCGGACAAGTTCCAAATACAGC
CATTGCCACAATCTGAAAACAAACTACAAACAGCACAGCAGCAACCACTACAGCAACTACAACAACAGCAGCAGTACCACCACCACCACG
CCCAGCAGTCAGCTGCAGCCTCTCCCAACCTGACTGCTTCACAGAAGACTGTAACTACAGCTTCTATGATTACCACAAAGACACTACCTC
TCGTCTTGAAAGCAGCAACTGCGACCATGCCTGCCTCTGTGGTGGGCCAGAGACCTACCATTGCTATGGTGACCGCCATCAACAGTCAGA
AGGCTGTGCTCAGCACTGATGTGCAGAACACACCAGTCAACCTCCAGACGTCTAGTAAGGTCACTGGGCCTGGGGCAGAGGCTGTCCAAA
TTGTGGCAAAAAACACAGTCACTCTGGTTCAGGCAACACCTCCTCAGCCCATCAAAGTACCACAGTTTATCCCCCCTCCTAGACTCACTC
CACGTCCAAACTTTCTTCCACAGGTTCGACCCAAGCCTGTGGCCCAGAATAACATTCCTATTGCCCCAGCACCACCTCCCATGCTCGCAG
CTCCTCAGCTTATCCAGAGGCCCGTCATGCTGACCAAGTTCACCCCCACAACCCTTCCCACATCCCAGAATTCCATCCACCCCGTCCGTG
TCGTCAATGGGCAGACTGCAACCATAGCCAAAACGTTCCCCATGGCCCAGCTCACCAGCATTGTGATAGCTACTCCAGGGACCAGACTCG
CTGGACCTCAAACTGTACAGCTTAGCAAGCCAAGTCTTGAAAAACAGACAGTTAAATCTCACACAGAAACAGATGAGAAACAAACAGAGA
GCCGCACCATCACCCCACCTGCTGCACCCAAACCAAAACGGGAGGAGAACCCTCAGAAACTTGCCTTCATGGTGTCTCTAGGGTTGGTAA
CACATGACCATCTAGAAGAAATCCAAAGCAAGAGGCAAGAGCGAAAAAGAAGAACAACAGCAAATCCGGTCTACAGTGGAGCAGTCTTTG
AGCCAGAGCGTAAGAAGAGTGCAGTGACATACCTAAACAGCACAATGCACCCTGGGACCCGGAAGAGAGGTCGTCCTCCAAAATACAATG
CAGTGCTGGGGTTTGGAGCCCTTACCCCAACATCCCCCCAATCCAGTCATCCTGACTCCCCTGAAAATGAAAAGACAGAGACCACATTCA
CTTTCCCTGCACCTGTTCAGCCTGTGTCCCTGCCCAGCCCCACCTCCACAGACGGTGATATTCATGAGGATTTTTGCAGCGTTTGCAGAA
AAAGTGGCCAGTTACTGATGTGCGACACATGTTCCCGTGTATATCATTTGGACTGCTTAGACCCCCCTCTGAAAACAATTCCCAAGGGCA
TGTGGATCTGTCCCAGATGTCAGGACCAGATGCTGAAGAAGGAAGAAGCAATTCCATGGCCTGGAACTTTAGCAATTGTTCATTCCTATA
TTGCCTACAAAGCAGCAAAAGAAGAAGAGAAACAGAAGTTACTTAAATGGAGTTCAGATTTAAAACAAGAACGAGAACAACTAGAGCAAA
AGGTGAAACAGCTCAGCAATTCCATAAGTAAATGCATGGAAATGAAGAACACCATCCTGGCCCGGCAGAAGGAGATGCACAGCTCCCTGG
AGAAGGTAAAACAGCTGATTCGCCTCATCCACGGCATCGACCTCTCCAAACCTGTAGACTCTGAGGCCACTGTGGGGGCCATCTCCAATG
GCCCGGACTGCACCCCCCCTGCCAATGCCGCCACCTCCACGCCGGCCCCTTCCCCCTCCTCCCAGAGCTGCACAGCGAACTGTAACCAGG
GGGAAGAGACTAAATAACAGAGCCCCTCTAGGAGAAGCCACGGGATCCCGGCGGCAAGGAGAACAGAACACTGAAGACTCTAGAAAAGCA
AAGCCGGATTTCTGGAAAGTGCAGAATTCTTTTGGTTCTTTGGTTCCAGAGAGAGAGAAGATGCTTGTGCCAGGTGGCACCAGAGTTTGC
CAATTGATCCTTCTTATTCTGTGTGTACATGCAAAGATTGGACCATGTTACATGAAATAGTGCCAGCTGGAGGTTCTTTGCCAGCACCAT
GCCAAGTGAAATAATATATTTACTCTCTCTATTATACACCAGTGTGTGCCTGCAGCAGCCTCCACAGCCACGATGGGTTTGTTTCTGTTT
TCTTGGGTGGGGAGCAGGGACGGGCGGAGGGAGGAGAGCAGGTTTCAGATCCTTACTTGCCGAGCCGTTTGTTTAGGTAGAGAAGACAAG


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FusionGenePPI for CLOCK_PHF21A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLOCKARNTL, ARNTL2, EP300, KAT2B, RXRA, RARA, SIRT1, TFAP4, SOX2, CIPC, CRY1, CRY2, DEC1, BHLHE41, NPAS2, PPP2R5D, PPP2R5E, CSNK2B, PPP2R1B, NR1D2, PER2, PPP1CA, PPP1CB, PPP1CC, RORB, CSNK1E, DBP, RORC, SRGAP3, TEKT4, CREBBP, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, GIT2, HAUS6, RPRD1A, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, KDM1A, RABEP1PHF21ALPXN, HDAC1, KDM1A, HMG20B, RCOR1, HDAC2, GTF2I, TAF10, ESCO2, HIST2H3C, ELAVL1, HIST3H3, FHL3, TRAF1, ZYX, NUP62, BANP, KRT40, SCLT1, CD14, KIF22, LLGL2, SOD1, MYH13, NUPL1, HMG20A, NAF1, IP6K3, RBPJ, EXOC1, MAX, ARNTL, RPRD1A, HAUS6, PHLDB3, PTRF, OIP5, CCDC93, CCDC132, DZIP3, GRIPAP1, VPS53, PSMD9, CLOCK, RABGAP1L, GOLGA5, TUFT1, YEATS4, CCHCR1, TFPT, NCKAP5L, PKN3, GIT2, RABGEF1, NUF2, THAP11, VPS51, JUN, TSSC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422371_845402847NR3C1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624371_845402847NR3C1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523371_845402847NR3C1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000309964-1422450_570402847SIRT1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000381322-1624450_570402847SIRT1
HgeneCLOCKchr4:56319221chr11:46001517ENST00000513440-1523450_570402847SIRT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLOCK_PHF21A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLOCK_PHF21A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLOCKC0005586Bipolar Disorder5PSYGENET
HgeneCLOCKC0011570Mental Depression5PSYGENET
HgeneCLOCKC0011581Depressive disorder5PSYGENET
HgeneCLOCKC0041696Unipolar Depression5PSYGENET
HgeneCLOCKC0525045Mood Disorders5PSYGENET
HgeneCLOCKC1269683Major Depressive Disorder5PSYGENET
HgeneCLOCKC0085159Seasonal Affective Disorder3PSYGENET
HgeneCLOCKC3496069cocaine use2PSYGENET
HgeneCLOCKC0001957Alcohol Withdrawal Delirium1PSYGENET
HgeneCLOCKC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneCLOCKC0036341Schizophrenia1PSYGENET
HgeneCLOCKC0600427Cocaine Dependence1PSYGENET