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Fusion gene ID: 7448 |
FusionGeneSummary for CLNS1A_AQP11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLNS1A_AQP11 | Fusion gene ID: 7448 | Hgene | Tgene | Gene symbol | CLNS1A | AQP11 | Gene ID | 1207 | 282679 |
| Gene name | chloride nucleotide-sensitive channel 1A | aquaporin 11 | |
| Synonyms | CLCI|CLNS1B|ICln | AQPX1 | |
| Cytomap | 11q14.1 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylosome subunit pIClnchloride channel regulatory proteinchloride channel, nucleotide sensitive 1Achloride conductance regulatory protein IClnchloride ion current inducer proteini(Cln)reticulocyte pIClnreticulocyte protein ICln | aquaporin-11AQP-11 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P54105 | Q8NBQ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000525428, ENST00000263309, ENST00000525064, ENST00000532069, ENST00000528364, ENST00000533957, | ENST00000528638, ENST00000313578, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 3 X 2 X 2=12 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/45*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLNS1A [Title/Abstract] AND AQP11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLNS1A | GO:0000387 | spliceosomal snRNP assembly | 18984161 |
| Tgene | AQP11 | GO:0006811 | ion transport | 16650285 |
| Tgene | AQP11 | GO:0006833 | water transport | 16650285 |
| Tgene | AQP11 | GO:0015793 | glycerol transport | 16650285 |
| Tgene | AQP11 | GO:0015840 | urea transport | 16650285 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A27G-01A | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000525428 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000525428 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000263309 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000263309 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000525064 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000525064 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| intron-3UTR | ENST00000532069 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| intron-3UTR | ENST00000532069 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000528364 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| 5CDS-3UTR | ENST00000528364 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| intron-3UTR | ENST00000533957 | ENST00000528638 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
| intron-3UTR | ENST00000533957 | ENST00000313578 | CLNS1A | chr11 | 77336008 | - | AQP11 | chr11 | 77314601 | + |
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FusionProtFeatures for CLNS1A_AQP11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLNS1A | AQP11 |