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Fusion gene ID: 7446 |
FusionGeneSummary for CLNK_CCT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLNK_CCT4 | Fusion gene ID: 7446 | Hgene | Tgene | Gene symbol | CLNK | CCT4 | Gene ID | 116449 | 10575 |
| Gene name | cytokine dependent hematopoietic cell linker | chaperonin containing TCP1 subunit 4 | |
| Synonyms | MIST | CCT-DELTA|Cctd|SRB | |
| Cytomap | 4p16.1 | 2p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer | T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z7G1 | P50991 | |
| Ensembl transtripts involved in fusion gene | ENST00000226951, ENST00000442825, ENST00000507719, ENST00000515667, | ENST00000394440, ENST00000461540, ENST00000544079, ENST00000544185, ENST00000538252, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 6 X 4=120 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLNK [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLNK | GO:0035556 | intracellular signal transduction | 10744659 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE698729 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000226951 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-5UTR | ENST00000226951 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000226951 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000226951 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000226951 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000442825 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-5UTR | ENST00000442825 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000442825 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000442825 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000442825 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000507719 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-5UTR | ENST00000507719 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000507719 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000507719 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000507719 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000515667 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-5UTR | ENST00000515667 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000515667 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000515667 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
| intron-3UTR | ENST00000515667 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
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FusionProtFeatures for CLNK_CCT4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLNK | CCT4 |