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Fusion gene ID: 7430 |
FusionGeneSummary for CLK4_ATP2C1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLK4_ATP2C1 | Fusion gene ID: 7430 | Hgene | Tgene | Gene symbol | CLK4 | ATP2C1 | Gene ID | 57396 | 27032 |
| Gene name | CDC like kinase 4 | ATPase secretory pathway Ca2+ transporting 1 | |
| Synonyms | - | ATP2C1A|BCPM|HHD|PMR1|SPCA1|hSPCA1 | |
| Cytomap | 5q35.3 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity protein kinase CLK4protein serine threonine kinase Clk4 | calcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1HUSSY-28secretory pathway Ca2+/Mn2+ ATPase 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HAZ1 | P98194 | |
| Ensembl transtripts involved in fusion gene | ENST00000316308, ENST00000522749, ENST00000520957, | ENST00000505330, ENST00000504381, ENST00000507488, ENST00000393221, ENST00000533801, ENST00000510168, ENST00000508532, ENST00000504948, ENST00000513801, ENST00000328560, ENST00000428331, ENST00000359644, ENST00000422190, ENST00000509150, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 3=108 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLK4 [Title/Abstract] AND ATP2C1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATP2C1 | GO:0006816 | calcium ion transport | 12810057 |
| Tgene | ATP2C1 | GO:0006874 | cellular calcium ion homeostasis | 12810057 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE698743 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000316308 | ENST00000505330 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000504381 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000507488 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000393221 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000533801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000510168 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000508532 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000504948 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000513801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000328560 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000428331 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000359644 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000422190 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000316308 | ENST00000509150 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000505330 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000504381 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000507488 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000393221 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000533801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000510168 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000508532 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000504948 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000513801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000328560 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000428331 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000359644 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000422190 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000522749 | ENST00000509150 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000505330 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000504381 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000507488 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000393221 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000533801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000510168 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000508532 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000504948 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000513801 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000328560 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000428331 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000359644 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000422190 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
| intron-intron | ENST00000520957 | ENST00000509150 | CLK4 | chr5 | 178043544 | + | ATP2C1 | chr3 | 130699208 | - |
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FusionProtFeatures for CLK4_ATP2C1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLK4 | ATP2C1 |