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Fusion gene ID: 7410 |
FusionGeneSummary for CLIP1_ZCCHC8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLIP1_ZCCHC8 | Fusion gene ID: 7410 | Hgene | Tgene | Gene symbol | CLIP1 | ZCCHC8 | Gene ID | 6249 | 55596 |
| Gene name | CAP-Gly domain containing linker protein 1 | zinc finger CCHC-type containing 8 | |
| Synonyms | CLIP|CLIP-170|CLIP170|CYLN1|RSN | - | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) | zinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P30622 | Q6NZY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000361654, ENST00000545889, ENST00000302528, ENST00000358808, ENST00000537178, ENST00000540338, ENST00000536634, ENST00000540539, | ENST00000536306, ENST00000543897, ENST00000336229, ENST00000538116, | |
| Fusion gene scores | * DoF score | 11 X 12 X 9=1188 | 4 X 5 X 5=100 |
| # samples | 16 | 7 | |
| ** MAII score | log2(16/1188*10)=-2.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLIP1 [Title/Abstract] AND ZCCHC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-ZF-AA51-01A | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| TCGA | RV | CESC | TCGA-ZJ-AAXN-01A | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| TCGA | RV | HNSC | TCGA-P3-A6T7-01A | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-intron | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-intron | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-intron | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-intron | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-5UTR | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-intron | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-intron | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-intron | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-5UTR | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| intron-intron | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122967242 | - |
| 5UTR-3CDS | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5UTR-3CDS | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| intron-3CDS | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122907068 | - | ZCCHC8 | chr12 | 122958822 | - |
| 5CDS-intron | ENST00000361654 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000361654 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000361654 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000361654 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000545889 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000545889 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000545889 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000545889 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000302528 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000302528 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000302528 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000302528 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000358808 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000358808 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000358808 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000358808 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000537178 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000537178 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000537178 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000537178 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000540338 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000540338 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-5UTR | ENST00000540338 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| 5CDS-intron | ENST00000540338 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000536634 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000536634 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000536634 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000536634 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000540539 | ENST00000536306 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000540539 | ENST00000543897 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-5UTR | ENST00000540539 | ENST00000336229 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
| intron-intron | ENST00000540539 | ENST00000538116 | CLIP1 | chr12 | 122861936 | - | ZCCHC8 | chr12 | 122968110 | - |
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FusionProtFeatures for CLIP1_ZCCHC8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLIP1 | ZCCHC8 |