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Fusion gene ID: 7385 |
FusionGeneSummary for CLIC4_CCDC28B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLIC4_CCDC28B | Fusion gene ID: 7385 | Hgene | Tgene | Gene symbol | CLIC4 | CCDC28B | Gene ID | 25932 | 79140 |
| Gene name | chloride intracellular channel 4 | coiled-coil domain containing 28B | |
| Synonyms | CLIC4L|H1|MTCLIC|huH1|p64H1 | - | |
| Cytomap | 1p36.11 | 1p35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chloride intracellular channel protein 4chloride intracellular channel 4 likeintracellular chloride ion channel protein p64H1 | coiled-coil domain-containing protein 28B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y696 | Q9BUN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000374379, ENST00000497755, | ENST00000373602, ENST00000421922, ENST00000483009, | |
| Fusion gene scores | * DoF score | 9 X 3 X 7=189 | 5 X 3 X 3=45 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/189*10)=-1.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLIC4 [Title/Abstract] AND CCDC28B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLIC4 | GO:0030336 | negative regulation of cell migration | 12163372 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-A39V-01A | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000374379 | ENST00000373602 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| 5CDS-5UTR | ENST00000374379 | ENST00000421922 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| 5CDS-3UTR | ENST00000374379 | ENST00000483009 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| 3UTR-5UTR | ENST00000497755 | ENST00000373602 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| 3UTR-5UTR | ENST00000497755 | ENST00000421922 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
| 3UTR-3UTR | ENST00000497755 | ENST00000483009 | CLIC4 | chr1 | 25072116 | + | CCDC28B | chr1 | 32667514 | + |
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FusionProtFeatures for CLIC4_CCDC28B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLIC4 | CCDC28B |