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Fusion gene ID: 7277 |
FusionGeneSummary for CKAP4_STYXL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CKAP4_STYXL1 | Fusion gene ID: 7277 | Hgene | Tgene | Gene symbol | CKAP4 | STYXL1 | Gene ID | 10970 | 51657 |
| Gene name | cytoskeleton associated protein 4 | serine/threonine/tyrosine interacting like 1 | |
| Synonyms | CLIMP-63|ERGIC-63|p63 | DUSP24|MK-STYX|MKSTYX | |
| Cytomap | 12q23.3 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoskeleton-associated protein 463 kDa membrane protein63-kDa cytoskeleton-linking membrane proteintransmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartmenttype-II transmembrane protein p63 | serine/threonine/tyrosine-interacting-like protein 1dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24map kinase phosphatase-like protein MK-STYX | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q07065 | Q9Y6J8 | |
| Ensembl transtripts involved in fusion gene | ENST00000552828, ENST00000378026, | ENST00000248600, ENST00000359697, ENST00000340062, ENST00000360591, ENST00000431581, ENST00000451157, ENST00000460184, | |
| Fusion gene scores | * DoF score | 3 X 5 X 1=15 | 6 X 4 X 5=120 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/15*10)=2.22239242133645 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CKAP4 [Title/Abstract] AND STYXL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STYXL1 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 24709986 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF902200 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000552828 | ENST00000248600 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000359697 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000340062 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000360591 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000431581 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000451157 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000552828 | ENST00000460184 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000248600 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000359697 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000340062 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000360591 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000431581 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000451157 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
| intron-intron | ENST00000378026 | ENST00000460184 | CKAP4 | chr12 | 106633770 | - | STYXL1 | chr7 | 75662949 | - |
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FusionProtFeatures for CKAP4_STYXL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CKAP4 | STYXL1 |