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Fusion gene ID: 7227 |
FusionGeneSummary for CIC_BOLA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CIC_BOLA2 | Fusion gene ID: 7227 | Hgene | Tgene | Gene symbol | CIC | BOLA2 | Gene ID | 23152 | 654483 |
| Gene name | capicua transcriptional repressor | bolA family member 2B | |
| Synonyms | MRD45 | BOLA2 | |
| Cytomap | 19q13.2 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein capicua homolog | bolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96RK0 | Q9H3K6 | |
| Ensembl transtripts involved in fusion gene | ENST00000572681, ENST00000575839, ENST00000160740, ENST00000575354, | ENST00000330978, | |
| Fusion gene scores | * DoF score | 9 X 7 X 5=315 | 19 X 26 X 1=494 |
| # samples | 9 | 28 | |
| ** MAII score | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/494*10)=-0.819084214639711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CIC [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BOLA2 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Tgene | BOLA2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD580494 | CIC | chr19 | 42799163 | + | BOLA2 | chr16 | 29999653 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000572681 | ENST00000330978 | CIC | chr19 | 42799163 | + | BOLA2 | chr16 | 29999653 | + |
| intron-intron | ENST00000575839 | ENST00000330978 | CIC | chr19 | 42799163 | + | BOLA2 | chr16 | 29999653 | + |
| 5CDS-intron | ENST00000160740 | ENST00000330978 | CIC | chr19 | 42799163 | + | BOLA2 | chr16 | 29999653 | + |
| 5CDS-intron | ENST00000575354 | ENST00000330978 | CIC | chr19 | 42799163 | + | BOLA2 | chr16 | 29999653 | + |
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FusionProtFeatures for CIC_BOLA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CIC | BOLA2 |