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Fusion gene ID: 7220 |
FusionGeneSummary for CIAO1_SERTAD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CIAO1_SERTAD2 | Fusion gene ID: 7220 | Hgene | Tgene | Gene symbol | CIAO1 | SERTAD2 | Gene ID | 9391 | 9792 |
| Gene name | cytosolic iron-sulfur assembly component 1 | SERTA domain containing 2 | |
| Synonyms | CIA1|WDR39 | Sei-2|TRIP-Br2|TRIPBR2 | |
| Cytomap | 2q11.2 | 2p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable cytosolic iron-sulfur protein assembly protein CIAO1WD repeat domain 39WD repeat-containing protein 39WD40 protein Ciao1cytosolic iron-sulfur protein assembly 1 homolog | SERTA domain-containing protein 2transcriptional regulator interacting with the PHD-bromodomain 2transcriptional regulator interacting with the PHS-bromodomain 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O76071 | Q14140 | |
| Ensembl transtripts involved in fusion gene | ENST00000488633, ENST00000469320, | ENST00000313349, ENST00000476805, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 4 X 1 X 4=16 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CIAO1 [Title/Abstract] AND SERTAD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SERTAD2 | GO:0030308 | negative regulation of cell growth | 16098148 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-56-5897-01A | CIAO1 | chr2 | 96934396 | + | SERTAD2 | chr2 | 64864009 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000488633 | ENST00000313349 | CIAO1 | chr2 | 96934396 | + | SERTAD2 | chr2 | 64864009 | - |
| 5CDS-5UTR | ENST00000488633 | ENST00000476805 | CIAO1 | chr2 | 96934396 | + | SERTAD2 | chr2 | 64864009 | - |
| intron-5UTR | ENST00000469320 | ENST00000313349 | CIAO1 | chr2 | 96934396 | + | SERTAD2 | chr2 | 64864009 | - |
| intron-5UTR | ENST00000469320 | ENST00000476805 | CIAO1 | chr2 | 96934396 | + | SERTAD2 | chr2 | 64864009 | - |
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FusionProtFeatures for CIAO1_SERTAD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CIAO1 | SERTAD2 |