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Fusion gene ID: 7212

FusionGeneSummary for CHTOP_S100A13

Fusion gene summary

Fusion gene information	Fusion gene name: CHTOP_S100A13
	Fusion gene ID: 7212
		Hgene	Tgene
	Gene symbol	CHTOP	S100A13
	Gene ID	26097	6284
	Gene name	chromatin target of PRMT1	S100 calcium binding protein A13
	Synonyms	C10orf77\|C1orf77\|FL-SRAG\|FOP\|SRAG\|SRAG-3\|SRAG-5\|pp7704	-
	Cytomap	1q21.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	chromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine	protein S100-A13
	Modification date	20180522	20180522
	UniProtAcc	Q9Y3Y2	Q99584
	Ensembl transtripts involved in fusion gene	ENST00000368694, ENST00000495554, ENST00000403433, ENST00000368690, ENST00000368687, ENST00000368686,	ENST00000339556, ENST00000392622, ENST00000392623, ENST00000440685, ENST00000368699, ENST00000491177,
Fusion gene scores	* DoF score	3 X 4 X 1=12	7 X 7 X 4=196
	# samples	5	8
	** MAII score	log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHTOP [Title/Abstract] AND S100A13 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHTOP	GO:0006406	mRNA export from nucleus	23299939
Hgene	CHTOP	GO:0032781	positive regulation of ATPase activity	23299939
Hgene	CHTOP	GO:0051096	positive regulation of helicase activity	23299939
Tgene	S100A13	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	15033494
Tgene	S100A13	GO:0050703	interleukin-1 alpha secretion	12746488

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI830371	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000368694	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000368694	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000368694	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000368694	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000368694	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000368694	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
3UTR-intron	ENST00000495554	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
5UTR-intron	ENST00000403433	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368690	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368687	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000339556	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000392622	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000392623	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000440685	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000368699	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+
intron-intron	ENST00000368686	ENST00000491177	CHTOP	chr1	153606824	+	S100A13	chr1	153604213	+

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FusionProtFeatures for CHTOP_S100A13

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHTOP Q9Y3Y2	S100A13 Q99584

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Fusion gene ID: 7212

FusionGeneSummary for CHTOP_S100A13

FusionProtFeatures for CHTOP_S100A13