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Fusion gene ID: 7210

FusionGeneSummary for CHTOP_CHTOP

Fusion gene summary

Fusion gene information	Fusion gene name: CHTOP_CHTOP
	Fusion gene ID: 7210
		Hgene	Tgene
	Gene symbol	CHTOP	CHTOP
	Gene ID	26097	26097
	Gene name	chromatin target of PRMT1	chromatin target of PRMT1
	Synonyms	C10orf77\|C1orf77\|FL-SRAG\|FOP\|SRAG\|SRAG-3\|SRAG-5\|pp7704	C10orf77\|C1orf77\|FL-SRAG\|FOP\|SRAG\|SRAG-3\|SRAG-5\|pp7704
	Cytomap	1q21.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	chromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine	chromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine
	Modification date	20180522	20180522
	UniProtAcc	Q9Y3Y2	Q9Y3Y2
	Ensembl transtripts involved in fusion gene	ENST00000368694, ENST00000495554, ENST00000403433, ENST00000368690, ENST00000368687, ENST00000368686,	ENST00000368694, ENST00000495554, ENST00000403433, ENST00000368690, ENST00000368687, ENST00000368686,
Fusion gene scores	* DoF score	3 X 4 X 1=12	2 X 3 X 1=6
	# samples	5	4
	** MAII score	log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/6*10)=2.73696559416621
Context	PubMed: CHTOP [Title/Abstract] AND CHTOP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHTOP	GO:0006406	mRNA export from nucleus	23299939
Hgene	CHTOP	GO:0032781	positive regulation of ATPase activity	23299939
Hgene	CHTOP	GO:0051096	positive regulation of helicase activity	23299939
Tgene	CHTOP	GO:0006406	mRNA export from nucleus	23299939
Tgene	CHTOP	GO:0032781	positive regulation of ATPase activity	23299939
Tgene	CHTOP	GO:0051096	positive regulation of helicase activity	23299939

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE866929	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
ChiTaRS3.1			CA428774	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
ChiTaRS3.1			BU618453	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000368694	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368694	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-3UTR	ENST00000495554	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000403433	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368690	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368687	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368686	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
5CDS-3UTR	ENST00000368694	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368694	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-intron	ENST00000495554	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000403433	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368690	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368687	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368686	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+

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FusionProtFeatures for CHTOP_CHTOP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHTOP Q9Y3Y2	CHTOP Q9Y3Y2

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Fusion gene ID: 7210

FusionGeneSummary for CHTOP_CHTOP

FusionProtFeatures for CHTOP_CHTOP