|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7203 |
FusionGeneSummary for CHSY1_SPOCK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHSY1_SPOCK2 | Fusion gene ID: 7203 | Hgene | Tgene | Gene symbol | CHSY1 | SPOCK2 | Gene ID | 22856 | 9806 |
| Gene name | chondroitin sulfate synthase 1 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 | |
| Synonyms | CHSY|CSS1|ChSy-1|TPBS | testican-2 | |
| Cytomap | 15q26.3 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chondroitin sulfate synthase 1N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1N-acetylgalactosaminyltransferase IIcarbohydrate synthase 1chondroitin glucuronyltransferase 1chondroitin glucuronyltransferase IIchondroitin synthase | testican-2SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86X52 | Q92563 | |
| Ensembl transtripts involved in fusion gene | ENST00000254190, ENST00000543813, | ENST00000536168, ENST00000373109, ENST00000317376, ENST00000460053, ENST00000412663, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CHSY1 [Title/Abstract] AND SPOCK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHSY1 | GO:0030206 | chondroitin sulfate biosynthetic process | 11514575 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A03P-01A | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000254190 | ENST00000536168 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| 5CDS-intron | ENST00000254190 | ENST00000373109 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| 5CDS-intron | ENST00000254190 | ENST00000317376 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| 5CDS-intron | ENST00000254190 | ENST00000460053 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| 5CDS-intron | ENST00000254190 | ENST00000412663 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| intron-intron | ENST00000543813 | ENST00000536168 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| intron-intron | ENST00000543813 | ENST00000373109 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| intron-intron | ENST00000543813 | ENST00000317376 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| intron-intron | ENST00000543813 | ENST00000460053 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
| intron-intron | ENST00000543813 | ENST00000412663 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
Top |
FusionProtFeatures for CHSY1_SPOCK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHSY1 | SPOCK2 |