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Fusion gene ID: 7169 |
FusionGeneSummary for CHRNA7_PRR16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHRNA7_PRR16 | Fusion gene ID: 7169 | Hgene | Tgene | Gene symbol | CHRNA7 | PRR16 | Gene ID | 89832 | 51334 |
| Gene name | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion | proline rich 16 | |
| Synonyms | CHRNA7|CHRNA7-DR1|D-10 | DSC54|LARGEN | |
| Cytomap | 15q13.2 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CHRNA7-FAM7A fusion proteinCHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusionCHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with seq | protein Largenmesenchymal stem cell protein DSC54proline-rich protein 16 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P36544 | Q569H4 | |
| Ensembl transtripts involved in fusion gene | ENST00000454250, ENST00000306901, ENST00000455693, | ENST00000407149, ENST00000379551, ENST00000505123, ENST00000446965, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 4=32 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHRNA7 [Title/Abstract] AND PRR16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRR16 | GO:0045727 | positive regulation of translation | 24656129 |
| Tgene | PRR16 | GO:0045793 | positive regulation of cell size | 24656129 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A8E0-01A | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000454250 | ENST00000407149 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| Frame-shift | ENST00000454250 | ENST00000379551 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5CDS-5UTR | ENST00000454250 | ENST00000505123 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5CDS-5UTR | ENST00000454250 | ENST00000446965 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| Frame-shift | ENST00000306901 | ENST00000407149 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| Frame-shift | ENST00000306901 | ENST00000379551 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5CDS-5UTR | ENST00000306901 | ENST00000505123 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5CDS-5UTR | ENST00000306901 | ENST00000446965 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5UTR-3CDS | ENST00000455693 | ENST00000407149 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5UTR-3CDS | ENST00000455693 | ENST00000379551 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5UTR-5UTR | ENST00000455693 | ENST00000505123 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
| 5UTR-5UTR | ENST00000455693 | ENST00000446965 | CHRNA7 | chr15 | 32323240 | + | PRR16 | chr5 | 120021649 | + |
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FusionProtFeatures for CHRNA7_PRR16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHRNA7 | PRR16 |