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Fusion gene ID: 7130 |
FusionGeneSummary for CHM_KCNIP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHM_KCNIP4 | Fusion gene ID: 7130 | Hgene | Tgene | Gene symbol | CHM | KCNIP4 | Gene ID | 1121 | 80333 |
| Gene name | CHM, Rab escort protein 1 | potassium voltage-gated channel interacting protein 4 | |
| Synonyms | DXS540|GGTA|HSD-32|REP-1|TCD | CALP|KCHIP4 | |
| Cytomap | Xq21.2 | 4p15.31-p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rab proteins geranylgeranyltransferase component A 1choroideremia (Rab escort protein 1) | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P24386 | Q6PIL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000357749, ENST00000467744, ENST00000537751, ENST00000358786, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 12 X 7 X 9=756 |
| # samples | 6 | 13 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHM [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHM | GO:0018344 | protein geranylgeranylation | 7957092 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-KU-A66T-01A | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| TCGA | LD | HNSC | TCGA-KU-A66T-01A | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357749 | ENST00000382148 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000357749 | ENST00000447367 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000357749 | ENST00000382150 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000357749 | ENST00000382152 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000509207 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000382149 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000359001 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382148 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000447367 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382150 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382152 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000509207 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000382149 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000359001 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000537751 | ENST00000382148 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000537751 | ENST00000447367 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000537751 | ENST00000382150 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| In-frame | ENST00000537751 | ENST00000382152 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000509207 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000382149 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000359001 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382148 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000447367 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382150 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382152 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000509207 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000382149 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000359001 | CHM | chrX | 85149193 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000357749 | ENST00000382148 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000357749 | ENST00000447367 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000357749 | ENST00000382150 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000357749 | ENST00000382152 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000509207 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000382149 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000357749 | ENST00000359001 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382148 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000447367 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382150 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000467744 | ENST00000382152 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000509207 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000382149 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000467744 | ENST00000359001 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000537751 | ENST00000382148 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000537751 | ENST00000447367 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000537751 | ENST00000382150 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| Frame-shift | ENST00000537751 | ENST00000382152 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000509207 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000382149 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| 5CDS-5UTR | ENST00000537751 | ENST00000359001 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382148 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000447367 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382150 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000358786 | ENST00000382152 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000509207 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000382149 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000358786 | ENST00000359001 | CHM | chrX | 85128057 | - | KCNIP4 | chr4 | 20852290 | - |
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FusionProtFeatures for CHM_KCNIP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHM | KCNIP4 |