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Fusion gene ID: 7074 |
FusionGeneSummary for CHIC2_MANBA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHIC2_MANBA | Fusion gene ID: 7074 | Hgene | Tgene | Gene symbol | CHIC2 | MANBA | Gene ID | 26511 | 4126 |
| Gene name | cysteine rich hydrophobic domain 2 | mannosidase beta | |
| Synonyms | BTL | MANB1 | |
| Cytomap | 4q12 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine-rich hydrophobic domain-containing protein 2BRX-like translocated in leukemiacystein-rich hydrophobic domain 2cysteine-rich hydrophobic domain 2 protein | beta-mannosidasebeta-mannosidase Alysosomal beta A mannosidasemannanasemannasemannosidase, beta A, lysosomal | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKJ5 | O00462 | |
| Ensembl transtripts involved in fusion gene | ENST00000263921, ENST00000512964, | ENST00000226578, ENST00000505239, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 4 X 4 X 4=64 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHIC2 [Title/Abstract] AND MANBA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-50-6592-01A | CHIC2 | chr4 | 54915122 | - | MANBA | chr4 | 103611928 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263921 | ENST00000226578 | CHIC2 | chr4 | 54915122 | - | MANBA | chr4 | 103611928 | - |
| Frame-shift | ENST00000263921 | ENST00000505239 | CHIC2 | chr4 | 54915122 | - | MANBA | chr4 | 103611928 | - |
| Frame-shift | ENST00000512964 | ENST00000226578 | CHIC2 | chr4 | 54915122 | - | MANBA | chr4 | 103611928 | - |
| Frame-shift | ENST00000512964 | ENST00000505239 | CHIC2 | chr4 | 54915122 | - | MANBA | chr4 | 103611928 | - |
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FusionProtFeatures for CHIC2_MANBA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHIC2 | MANBA |