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Fusion gene ID: 7034 |
FusionGeneSummary for CHD9_DLC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD9_DLC1 | Fusion gene ID: 7034 | Hgene | Tgene | Gene symbol | CHD9 | DLC1 | Gene ID | 80205 | 10395 |
| Gene name | chromodomain helicase DNA binding protein 9 | DLC1 Rho GTPase activating protein | |
| Synonyms | AD013|CHD-9|CReMM|KISH2|PRIC320 | ARHGAP7|HP|STARD12|p122-RhoGAP | |
| Cytomap | 16q12.2 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 9ATP-dependent helicase CHD9PPAR-alpha-interacting complex protein 320 kDaPPAR{gamma}-interacting cofactor 320 kDachromatin remodeling factor CHROM1chromatin-related mesenchymal modulatorciprofibrate bound p | rho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q3L8U1 | Q96QB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000447540, ENST00000566029, ENST00000564845, ENST00000398510, ENST00000564582, | ENST00000276297, ENST00000358919, ENST00000512044, ENST00000316609, ENST00000511869, ENST00000510318, ENST00000520226, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 8 X 7 X 4=224 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHD9 [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DLC1 | GO:0006915 | apoptotic process | 17292327 |
| Tgene | DLC1 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17888903 |
| Tgene | DLC1 | GO:0008285 | negative regulation of cell proliferation | 12545165|17932950 |
| Tgene | DLC1 | GO:0030336 | negative regulation of cell migration | 17932950|19158340 |
| Tgene | DLC1 | GO:0035307 | positive regulation of protein dephosphorylation | 17292327 |
| Tgene | DLC1 | GO:0051497 | negative regulation of stress fiber assembly | 17932950 |
| Tgene | DLC1 | GO:0051895 | negative regulation of focal adhesion assembly | 19158340 |
| Tgene | DLC1 | GO:1900119 | positive regulation of execution phase of apoptosis | 17888903 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A1AN-01A | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000447540 | ENST00000276297 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000358919 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000512044 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000316609 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000511869 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000510318 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000447540 | ENST00000520226 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| Frame-shift | ENST00000566029 | ENST00000276297 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000358919 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000512044 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000316609 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000511869 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000510318 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000566029 | ENST00000520226 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| Frame-shift | ENST00000564845 | ENST00000276297 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000358919 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000512044 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000316609 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000511869 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000510318 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000564845 | ENST00000520226 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| Frame-shift | ENST00000398510 | ENST00000276297 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000358919 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000512044 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000316609 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000511869 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000510318 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| 5CDS-intron | ENST00000398510 | ENST00000520226 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-3CDS | ENST00000564582 | ENST00000276297 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000358919 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000512044 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000316609 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000511869 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000510318 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
| intron-intron | ENST00000564582 | ENST00000520226 | CHD9 | chr16 | 53308214 | + | DLC1 | chr8 | 13162811 | - |
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FusionProtFeatures for CHD9_DLC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD9 | DLC1 |