|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7013 |
FusionGeneSummary for CHD6_ZNF235 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD6_ZNF235 | Fusion gene ID: 7013 | Hgene | Tgene | Gene symbol | CHD6 | ZNF235 | Gene ID | 84181 | 9310 |
| Gene name | chromodomain helicase DNA binding protein 6 | zinc finger protein 235 | |
| Synonyms | CHD-6|CHD5|RIGB | ANF270|HZF6|ZFP93|ZNF270 | |
| Cytomap | 20q12 | 19q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | zinc finger protein 235zfp-93zinc finger protein 270zinc finger protein 6zinc finger protein 93 homologzinc finger protein HZF6zinc finger protein homologous to Zfp93 in mousezinc finger protein homologous to mouse Zfp93 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TD26 | Q14590 | |
| Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000589799, ENST00000589248, ENST00000291182, | |
| Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 2 X 2 X 2=8 |
| # samples | 25 | 2 | |
| ** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CHD6 [Title/Abstract] AND ZNF235 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XD-01A | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000373233 | ENST00000589799 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| 5CDS-intron | ENST00000373233 | ENST00000589248 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| 5CDS-intron | ENST00000373233 | ENST00000291182 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| 5CDS-intron | ENST00000309279 | ENST00000589799 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| 5CDS-intron | ENST00000309279 | ENST00000589248 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| 5CDS-intron | ENST00000309279 | ENST00000291182 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000373222 | ENST00000589799 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000373222 | ENST00000589248 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000373222 | ENST00000291182 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000480022 | ENST00000589799 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000480022 | ENST00000589248 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
| intron-intron | ENST00000480022 | ENST00000291182 | CHD6 | chr20 | 40080466 | - | ZNF235 | chr19 | 44739022 | - |
Top |
FusionProtFeatures for CHD6_ZNF235 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD6 | ZNF235 |