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Fusion gene ID: 7009 |
FusionGeneSummary for CHD6_SPEN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD6_SPEN | Fusion gene ID: 7009 | Hgene | Tgene | Gene symbol | CHD6 | SPEN | Gene ID | 84181 | 64783 |
| Gene name | chromodomain helicase DNA binding protein 6 | RNA binding motif protein 15 | |
| Synonyms | CHD-6|CHD5|RIGB | OTT|OTT1|SPEN | |
| Cytomap | 20q12 | 1p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | putative RNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TD26 | Q96T58 | |
| Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000375759, ENST00000471538, | |
| Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 4 X 5 X 2=40 |
| # samples | 25 | 9 | |
| ** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/40*10)=1.16992500144231 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHD6 [Title/Abstract] AND SPEN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPEN | GO:0045892 | negative regulation of transcription, DNA-templated | 16129689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | THYM | TCGA-ZB-A969-01A | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000373233 | ENST00000375759 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| 5UTR-intron | ENST00000373233 | ENST00000471538 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| 5UTR-3CDS | ENST00000309279 | ENST00000375759 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| 5UTR-intron | ENST00000309279 | ENST00000471538 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| 5UTR-3CDS | ENST00000373222 | ENST00000375759 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| 5UTR-intron | ENST00000373222 | ENST00000471538 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| intron-3CDS | ENST00000480022 | ENST00000375759 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
| intron-intron | ENST00000480022 | ENST00000471538 | CHD6 | chr20 | 40246979 | - | SPEN | chr1 | 16199311 | + |
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FusionProtFeatures for CHD6_SPEN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD6 | SPEN |