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Fusion gene ID: 7008 |
FusionGeneSummary for CHD6_SNX21 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD6_SNX21 | Fusion gene ID: 7008 | Hgene | Tgene | Gene symbol | CHD6 | SNX21 | Gene ID | 84181 | 90203 |
| Gene name | chromodomain helicase DNA binding protein 6 | sorting nexin family member 21 | |
| Synonyms | CHD-6|CHD5|RIGB | C20orf161|PP3993|SNX-L|dJ337O18.4 | |
| Cytomap | 20q12 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | sorting nexin-21sorting nexin L | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8TD26 | Q969T3 | |
| Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000462307, ENST00000491381, ENST00000342644, ENST00000372542, ENST00000372541, ENST00000344780, | |
| Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 1 X 1 X 1=1 |
| # samples | 25 | 1 | |
| ** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CHD6 [Title/Abstract] AND SNX21 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-J9-A8CN-01A | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000373233 | ENST00000462307 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| 5CDS-intron | ENST00000373233 | ENST00000491381 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| 5CDS-intron | ENST00000373233 | ENST00000342644 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| 5CDS-intron | ENST00000373233 | ENST00000372542 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| 5CDS-intron | ENST00000373233 | ENST00000372541 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| 5CDS-intron | ENST00000373233 | ENST00000344780 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000462307 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000491381 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000342644 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000372542 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000372541 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000309279 | ENST00000344780 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000462307 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000491381 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000342644 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000372542 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000372541 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000373222 | ENST00000344780 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000462307 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000491381 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000342644 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000372542 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000372541 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
| intron-intron | ENST00000480022 | ENST00000344780 | CHD6 | chr20 | 40043825 | - | SNX21 | chr20 | 44469072 | + |
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FusionProtFeatures for CHD6_SNX21 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD6 | SNX21 |