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Fusion gene ID: 7003 |
FusionGeneSummary for CHD6_MYH7B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD6_MYH7B | Fusion gene ID: 7003 | Hgene | Tgene | Gene symbol | CHD6 | MYH7B | Gene ID | 84181 | 57644 |
| Gene name | chromodomain helicase DNA binding protein 6 | myosin heavy chain 7B | |
| Synonyms | CHD-6|CHD5|RIGB | MHC14|MYH14 | |
| Cytomap | 20q12 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | myosin-7BU937-associated antigenantigen MLAA-21myosin heavy chain 7B, cardiac muscle beta isoformmyosin, heavy chain 7B, cardiac muscle, betamyosin, heavy polypeptide 7B, cardiac muscle, betaslow A MYH14 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8TD26 | A7E2Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000262873, ENST00000481922, | |
| Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 2 X 2 X 2=8 |
| # samples | 25 | 2 | |
| ** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CHD6 [Title/Abstract] AND MYH7B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2Q-01A | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000373233 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| 5CDS-intron | ENST00000373233 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| Frame-shift | ENST00000309279 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| 5CDS-intron | ENST00000309279 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| intron-3CDS | ENST00000373222 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| intron-intron | ENST00000373222 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| intron-3CDS | ENST00000480022 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
| intron-intron | ENST00000480022 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
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FusionProtFeatures for CHD6_MYH7B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD6 | MYH7B |