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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 6994

FusionGeneSummary for CHD6_CHD6

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD6_CHD6
Fusion gene ID: 6994
HgeneTgene
Gene symbol

CHD6

CHD6

Gene ID

84181

84181

Gene namechromodomain helicase DNA binding protein 6chromodomain helicase DNA binding protein 6
SynonymsCHD-6|CHD5|RIGBCHD-6|CHD5|RIGB
Cytomap

20q12

20q12

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B proteinchromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein
Modification date2018051920180519
UniProtAcc

Q8TD26

Q8TD26

Ensembl transtripts involved in fusion geneENST00000373233, ENST00000309279, 
ENST00000373222, ENST00000480022, 
ENST00000373233, ENST00000309279, 
ENST00000373222, ENST00000480022, 
Fusion gene scores* DoF score22 X 14 X 10=30808 X 9 X 4=288
# samples 2510
** MAII scorelog2(25/3080*10)=-3.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD6 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA120241CHD6chr20

40141485

-CHD6chr20

40162211

-
ChiTaRS3.1AK026022CHD6chr20

40050694

-CHD6chr20

40247063

-
ChiTaRS3.1AI312497CHD6chr20

40141485

-CHD6chr20

40143593

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000373233ENST00000373233CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000373233ENST00000309279CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000373233ENST00000373222CHD6chr20

40141485

-CHD6chr20

40162211

-
5CDS-intronENST00000373233ENST00000480022CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000309279ENST00000373233CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000309279ENST00000309279CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000309279ENST00000373222CHD6chr20

40141485

-CHD6chr20

40162211

-
5CDS-intronENST00000309279ENST00000480022CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000373222ENST00000373233CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000373222ENST00000309279CHD6chr20

40141485

-CHD6chr20

40162211

-
Frame-shiftENST00000373222ENST00000373222CHD6chr20

40141485

-CHD6chr20

40162211

-
5CDS-intronENST00000373222ENST00000480022CHD6chr20

40141485

-CHD6chr20

40162211

-
intron-3CDSENST00000480022ENST00000373233CHD6chr20

40141485

-CHD6chr20

40162211

-
intron-3CDSENST00000480022ENST00000309279CHD6chr20

40141485

-CHD6chr20

40162211

-
intron-3CDSENST00000480022ENST00000373222CHD6chr20

40141485

-CHD6chr20

40162211

-
intron-intronENST00000480022ENST00000480022CHD6chr20

40141485

-CHD6chr20

40162211

-
intron-5UTRENST00000373233ENST00000373233CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000373233ENST00000309279CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000373233ENST00000373222CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000373233ENST00000480022CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000309279ENST00000373233CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000309279ENST00000309279CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000309279ENST00000373222CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000309279ENST00000480022CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000373222ENST00000373233CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000373222ENST00000309279CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000373222ENST00000373222CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000373222ENST00000480022CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000480022ENST00000373233CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-5UTRENST00000480022ENST00000309279CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000480022ENST00000373222CHD6chr20

40050694

-CHD6chr20

40247063

-
intron-intronENST00000480022ENST00000480022CHD6chr20

40050694

-CHD6chr20

40247063

-
In-frameENST00000373233ENST00000373233CHD6chr20

40141485

-CHD6chr20

40143593

-
In-frameENST00000373233ENST00000309279CHD6chr20

40141485

-CHD6chr20

40143593

-
In-frameENST00000373233ENST00000373222CHD6chr20

40141485

-CHD6chr20

40143593

-
5CDS-intronENST00000373233ENST00000480022CHD6chr20

40141485

-CHD6chr20

40143593

-
In-frameENST00000309279ENST00000373233CHD6chr20

40141485

-CHD6chr20

40143593

-
In-frameENST00000309279ENST00000309279CHD6chr20

40141485

-CHD6chr20

40143593

-
In-frameENST00000309279ENST00000373222CHD6chr20

40141485

-CHD6chr20

40143593

-
5CDS-intronENST00000309279ENST00000480022CHD6chr20

40141485

-CHD6chr20

40143593

-
Frame-shiftENST00000373222ENST00000373233CHD6chr20

40141485

-CHD6chr20

40143593

-
Frame-shiftENST00000373222ENST00000309279CHD6chr20

40141485

-CHD6chr20

40143593

-
Frame-shiftENST00000373222ENST00000373222CHD6chr20

40141485

-CHD6chr20

40143593

-
5CDS-intronENST00000373222ENST00000480022CHD6chr20

40141485

-CHD6chr20

40143593

-
intron-3CDSENST00000480022ENST00000373233CHD6chr20

40141485

-CHD6chr20

40143593

-
intron-3CDSENST00000480022ENST00000309279CHD6chr20

40141485

-CHD6chr20

40143593

-
intron-3CDSENST00000480022ENST00000373222CHD6chr20

40141485

-CHD6chr20

40143593

-
intron-intronENST00000480022ENST00000480022CHD6chr20

40141485

-CHD6chr20

40143593

-

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FusionProtFeatures for CHD6_CHD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD6

Q8TD26

CHD6

Q8TD26


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-5793_202319374Compositional biasNote=Lys-rich
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-53793_2022842716Compositional biasNote=Lys-rich
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-271449_1503219374DomainNote=Myb-like
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27292_343219374DomainChromo 1
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27375_439219374DomainChromo 2
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27473_647219374DomainHelicase ATP-binding
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27787_956219374DomainHelicase C-terminal
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-2371449_15031842716DomainNote=Myb-like
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237292_3431842716DomainChromo 1
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237375_4391842716DomainChromo 2
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237473_6471842716DomainHelicase ATP-binding
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237787_9561842716DomainHelicase C-terminal
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27598_601219374MotifNote=DEAH box
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237598_6011842716MotifNote=DEAH box
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-27486_493219374Nucleotide bindingATP
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-237486_4931842716Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-571449_1503319374DomainNote=Myb-like
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57292_343319374DomainChromo 1
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57375_439319374DomainChromo 2
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57473_647319374DomainHelicase ATP-binding
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57787_956319374DomainHelicase C-terminal
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-5371449_15032842716DomainNote=Myb-like
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537292_3432842716DomainChromo 1
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537375_4392842716DomainChromo 2
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537473_6472842716DomainHelicase ATP-binding
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537787_9562842716DomainHelicase C-terminal
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57598_601319374MotifNote=DEAH box
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537598_6012842716MotifNote=DEAH box
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-57486_493319374Nucleotide bindingATP
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-537486_4932842716Nucleotide bindingATP
HgeneCHD6chr20:40141485chr20:40143593ENST00000373222-571_747319374RegionNote=Required for DNA-dependent ATPase activity
HgeneCHD6chr20:40141485chr20:40143593ENST00000373233-5371_7472842716RegionNote=Required for DNA-dependent ATPase activity
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-2793_202219374Compositional biasNote=Lys-rich
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-23793_2021842716Compositional biasNote=Lys-rich
TgeneCHD6chr20:40141485chr20:40143593ENST00000373222-271_747219374RegionNote=Required for DNA-dependent ATPase activity
TgeneCHD6chr20:40141485chr20:40143593ENST00000373233-2371_7471842716RegionNote=Required for DNA-dependent ATPase activity


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FusionGeneSequence for CHD6_CHD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHD6_CHD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHD6AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFRCHD6AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHD6_CHD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHD6_CHD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHD6C0005695Bladder Neoplasm1CTD_human
HgeneCHD6C0007138Carcinoma, Transitional Cell1CTD_human
HgeneCHD6C0027819Neuroblastoma1CTD_human
TgeneCHD6C0005695Bladder Neoplasm1CTD_human
TgeneCHD6C0007138Carcinoma, Transitional Cell1CTD_human
TgeneCHD6C0027819Neuroblastoma1CTD_human