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Fusion gene ID: 6935 |
FusionGeneSummary for CHAMP1_COL4A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHAMP1_COL4A2 | Fusion gene ID: 6935 | Hgene | Tgene | Gene symbol | CHAMP1 | COL4A2 | Gene ID | 283489 | 1284 |
| Gene name | chromosome alignment maintaining phosphoprotein 1 | collagen type IV alpha 2 chain | |
| Synonyms | C13orf8|CAMP|CHAMP|MRD40|ZNF828 | ICH|POREN2 | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromosome alignment-maintaining phosphoprotein 1zinc finger protein 828 | collagen alpha-2(IV) chaincanstatin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96JM3 | P08572 | |
| Ensembl transtripts involved in fusion gene | ENST00000361283, ENST00000478022, | ENST00000360467, ENST00000462309, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 3=108 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHAMP1 [Title/Abstract] AND COL4A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COL4A2 | GO:0016525 | negative regulation of angiogenesis | 10625665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A922-01A | CHAMP1 | chr13 | 115086707 | + | COL4A2 | chr13 | 111160282 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000361283 | ENST00000360467 | CHAMP1 | chr13 | 115086707 | + | COL4A2 | chr13 | 111160282 | + |
| 5UTR-intron | ENST00000361283 | ENST00000462309 | CHAMP1 | chr13 | 115086707 | + | COL4A2 | chr13 | 111160282 | + |
| 3UTR-3CDS | ENST00000478022 | ENST00000360467 | CHAMP1 | chr13 | 115086707 | + | COL4A2 | chr13 | 111160282 | + |
| 3UTR-intron | ENST00000478022 | ENST00000462309 | CHAMP1 | chr13 | 115086707 | + | COL4A2 | chr13 | 111160282 | + |
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FusionProtFeatures for CHAMP1_COL4A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHAMP1 | COL4A2 |